安徽医科大学学报2018，Vol.53Issue(3)：382-385,4.DOI:10.19405/j.cnki.issn1000-1492.2018.03.011
ADMA在交感神经损毁自发性高血压大鼠中的作用
Effect of ADMA in sympathectomized spontaneously hypertensive rat
摘要
Abstract
Objective To explore the role of asymmetric dimethylarginine(ADMA) in sympathectomized spontaneously hypertensive rat(SHR). Methods SHR pups were pharmacologically sympathectomized to investigate the role of sympathetic activity on ADMA. Systolic and diastolic blood pressure was monitored by tail-cuff method. Urine norepinephrine(NE) excretion of 6 hours collected using metabolic cages was detected. The levels of L-Arginine, ADMA, symmetric dimethylarginine and NE were evaluated in kidneys, heart and aorta in SHR by HPLC. No content and NOS activity in SHR kidney were determined by colorimetry. Results Neonatal chemical sympathectomy elicited a marked reduction of urinary NE excretion and NE contents in kidneys, heart and aorta and in the sympathectomized SHR compared with the sympathetically-intact SHR (P＜0. 01). Sympathectomy resulted in a reduction of systolic blood pressure and diastolic blood pressure in 12 week old SHR compared with the sympathetically-intact SHR (P＜0. 01). The sympathectomized SHR had a significant lower renal ADMA content than the sympathetically-intact SHR, moreover, the levels of NO content and NOS activity increased (P＜0.05). Conclusion Sympathetic nerve system may regulate blood pressure by ADMA.关键词
交感神经系统/不对称二甲基精氨酸/去甲肾上腺素/自发性高血压大鼠/一氧化氮Key words
sympathetic nerve system/ADMA/NE/SHR/NO分类
医药卫生引用本文复制引用
肖冰,杨秀春,鲁静朝,王梦肖,陈会强,李玥,郝杰,靳雅琼,刘凡..ADMA在交感神经损毁自发性高血压大鼠中的作用[J].安徽医科大学学报,2018,53(3):382-385,4.基金项目
河北省医学科学研究课题(编号:20130171) （编号:20130171）
河北省自然科学基金青年科学基金(编号:H2015206442) （编号:H2015206442）
河北省引进留学人员资助项目(课题)(编号:C201400335) （课题）
