安徽医科大学学报2018，Vol.53Issue(3)：420-424,5.DOI:10.19405/j.cnki.issn1000-1492.2018.03.019
SLC12A5和Ki-67在结直肠癌中的表达及临床意义
Expressions of SLC12A5 and Ki-67 in colorectal cancer tissues and its clinical significance
摘要
Abstract
Objective To explore the expressions of SLC12A5 and Ki-67 in human colorectal adenocarcinoma tissues and discuss the clinical significances. Methods The expressions of SLC12A5 and Ki-67 in 40 specimens of colorectal adenocarcinoma tissues (cancer group), 30 specimens of colorectal adenoma tissues (adenoma group) and 40 specimens of normal colorectal tissues (normal group) were selected and immunohistochemistry technique was used to detect the expression of SLC12A5 and Ki-67. The correlation between their positive expression and the elinieopathologie features were analyzed. Results The positive rates of SLC12A5 in cancer group, adenoma group and normal group were 87. 50％ (35/40), 46. 67％ (14/30) and 32. 50％ (13/40) respectively, the difference was statistically significant (P＜ 0. 05). The positive rates of Ki-67 in the cancer group, adenoma group and normal group were 82.50％ (33/40), 50. 00％ (15/30) and 20. 00％ (8/40) respectively, the difference was statistically significant. The positive rates of SLC12A5 in cancer group, adenoma group and normal group were 87. 50％(35/40), 46, 67％ (14/30) and 32. 50％ (13/40) respectively, the difference was statistically significant (P＜0. 05). The positive rates of Ki-67 in the cancer group, adenoma group and normal group were 82. 50％ (33/40), 50. 00％ (15/30) and 20. 00％ (8/40) respectively, the difference was statistically significant(P＜0. 05). Expression of SLC12A5 was positively related with expression of Ki-67 in esophageal squamous cell carcinoma tissues(r =0. 518, P =0. 000). The positive expression of SLC12A5 and Ki-67 were correlated with the depth of tumor invasion, TNM stage, lymph node metastasis, liver metastasis and vessel invasion (P＜ 0. 05). Conclusion The expression levels of SLC12A5 and Ki-67 are higher in colorectal adenocarcinoma tissues, which have correlation with the depth of tumor invasion, TNM stage, lymph node metastasis, vessel invasion and liver metastasis.关键词
SLC12A5/Ki-67/结直肠肿瘤/免疫组化/临床病理特征/临床意义Key words
SLC12A5/Ki-67/colorectal neoplasms/immunohistochemistry/clinicopathological features/clinical significance分类
医药卫生引用本文复制引用
王晓元,赵轶峰,杨永江,武雪亮,李坤,李曙光..SLC12A5和Ki-67在结直肠癌中的表达及临床意义[J].安徽医科大学学报,2018,53(3):420-424,5.基金项目
河北省卫计委医学科研重点计划(编号:20160364) （编号:20160364）
张家口市科技局指导性计划(编号:1621068D) （编号:1621068D）
