安徽医科大学学报2018，Vol.53Issue(3)：480-483,490,5.DOI:10.19405/j.cnki.issn1000-1492.2018.03.033
替加环素对复杂性腹腔感染患者免疫功能影响
Effects of tigecycline on immune function in patients with complicated abdominal infection
摘要
Abstract
Objective To study the effects of tigecycline on immune function in patients with complicated intra-abdominal infections (cIAI). Methods A total of 24 cIAI patients received treatment of tigecycline, and then the effects of tigecycline on level of peripheral blood monouclear cells (PBMC) proliferation, concentration of inflammatory cytokines, and expression of CD3, CD4 and CD8 were investigated. Results The total effective rates of tigecycline were 70. 8％. Tigecycline treatment significantly reduced proliferative level of PBMC, decreased the levels of interleukin-1β (IL-1β), IL-6 and IL-8 in supernatants of PBMC cultures as well as serum. Moreover, tigecycline therapy significantly up-regulated the percentage of CD3 + and CD4 +, increased the ratio of CD4+ / CD8 +, and down-regulated percentage of CD8 + in peripheral blood. Conclusion Tigecycline could regulate immune function in cIAI patients.关键词
替加环素/复杂性腹腔感染/炎症/外周血单核细胞/细胞因子Key words
tigecycline/complicated intra-abdominal infections/inflammation/peripheral blood monouclear cells/cytokines分类
医药卫生引用本文复制引用
郭茂松,余维丽,孙昀..替加环素对复杂性腹腔感染患者免疫功能影响[J].安徽医科大学学报,2018,53(3):480-483,490,5.基金项目
安徽省自然科学基金(编号:1508085QC49 ) （编号:1508085QC49 ）
