安徽医科大学学报2018，Vol.53Issue(6)：902-907,6.DOI:10.19405/j.cnki.issn1000-1492.2018.06.016
利拉鲁肽对动脉硬化大鼠模型的疗效评价
Efficacy of liraglutide on atherosclerotic rat model
摘要
Abstract
Objective The curative effect of liraglutide on rat model of atherosclerosis induced by high fat was e-valuated according to vascular tone, vascular pathology and serological indexes. Methods Thirty SDF male rats were randomly divided into high fat group ( n=20) and control group ( n=12) . The successful model of high fat group were randomly divided into liraglutide group and placebo group, and continue to be given high-fat diet,re-spectively,while subcutaneous injection of liraglutide or saline, the control group continue to be fed ordinary feed. At the end of the 16th week of intervention, serum triglyceride (TG), total cholesterol (CHO), low density lipo-protein ( LDL) , fasting blood glucose ( FBG) and fasting insulin ( FINS) were measured; the changes of vascular endothelial function were evaluated by the level of serum nitric oxide (NO) and endothelin 1 (ET-1); the vascular wall was observed by HE staining and Masson staining; the vascular tension was detected by aorta-ring apparatus. The data were analyzed by means of homogeneity of variance. Results Compared with placebo group, the levels of serum TG, CHO, LDL, FINS and ET-1 in liraglutide group were significantly decreased (P＜0.05) and NO levels were increased ( P＜0.05) ; the results of vascular pathology showed that the degree of vascular endothelial injury was significantly reduced and the proliferation and migration of vascular smooth muscle cells were decreased; the results of aorta-ring results showed that the vasodilation of liraglutide group was significantly improved ( P＜0.05) . Conclusion liraglutide can significantly reduce the vascular endothelial injury induced by high-fat diet, protect endothelial cells and inhibit the proliferation and migration of smooth muscle cells, which may become a new drug to improve the degree of atherosclerosis.关键词
利拉鲁肽/动脉硬化/血管张力/内皮素1/一氧化氮Key words
liraglutide/atherosclerosis/vascular tension/endothelin 1/nitric oxide分类
医药卫生引用本文复制引用
郭晶晶,李娜,霍琴琴,钟兴,潘天荣..利拉鲁肽对动脉硬化大鼠模型的疗效评价[J].安徽医科大学学报,2018,53(6):902-907,6.基金项目
安徽省科技厅公益性技术应用研究联动项目(编号:1501ld04042) （编号:1501ld04042）
安徽省高等学校自然科学研究重点项目(编号:KJ2017A174、KJ2018A0202) （编号:KJ2017A174、KJ2018A0202）
