安徽医科大学学报2018，Vol.53Issue(6)：955-960,6.DOI:10.19405/j.cnki.issn1000-1492.2018.06.027
维持性血液透析患者载脂蛋白E基因多态性与心血管并发症的关系
Relationship between apolipoprotein E gene polymorphism and cardiovascular complications in maintenance hemodialysis patients
摘要
Abstract
Objective To investigate the association between apolipoprotein E ( ApoE) gene polymorphism and cardiovascular complications in maintenance hemodialysis ( MHD) patients. Methods 189 end stage renal disease (ESRD) patients with MHD (experimental group) and 165 healthy people (control group) were selected. Serum levels of serum creatinine ( Scr) , blood urea nitrogen ( BUN) , total cholesterol ( TC) , albumin ( ALB) , triglycer- ide ( TG) , HDL-C and LDL-C were measured. ApoE gene polymorphism was detected by PCR-RFLP. The compo-nents were divided into ε 2, ε 3 and ε 4 groups by genotype. The biochemical indexes, the incidence of cardiovas-cular complications and the frequency of distribution were compared between the two groups. Results Compared with the control group, the levels of adiponectin, Scr, BUN, TC, TG and LDL-C were increased and the levels of albumin and HDL-C were decreased in the experimental group. The frequency of ε 3/3 genotype and ε 3 allele were decreased significantly, while ε 4/3 and ε 4 were increased remarkable in the experimental group as compared with those in the control group. The levels of adiponectin, Scr, BUN and TC in the ε 4 group were elevated,as well as incidences of hypotension, hypertension, coronary heart disease and chronic heart failure, but the level of of HDL-C were reduced compared with other groups, The logistic regression analysis confirmed that the ε 3/3 geno-type and the ε 3 allele were protective factors, but the ε 4/3 genotype and the ε 4 allele were risk factors for cardi-ovascular complications in ESRD with MHD patients. Conclusion This study demonstrates that ApoE gene poly-morphism affects the occurrence and development of cardiovascular complications in MHD patients of ESRD to a certain extent,and ε 4/3 genotype, ε 4 allele are risk factors for cardiovascular disease of ESRD patients on MHD.关键词
ApoE/基因多态性/终末期肾病/维持性血液透析/心血管并发症Key words
ApoE/gene polymorphism/end stage renal disease/maintenance hemodialysis/cardiovascular com-plications分类
医药卫生引用本文复制引用
郑昌志,王娟,齐向明,吴永贵..维持性血液透析患者载脂蛋白E基因多态性与心血管并发症的关系[J].安徽医科大学学报,2018,53(6):955-960,6.基金项目
安徽省高校自然科学研究重点项目(编号:KJ2016A343) （编号:KJ2016A343）
