安徽医科大学学报2018，Vol.53Issue(7)：1085-1088,4.DOI:10.19405/j.cnki.issn1000-1492.2018.07.020
血清脂肪细胞型脂肪酸结合蛋白和白细胞介素-17水平与2型糖尿病患者下肢动脉粥样硬化病变的相关性研究
The study on the correlation between serum adipocyte fatty acid binding protein and interleukin 17 levels and lower extremity atherosclerotic disease in type 2 diabetes
摘要
Abstract
Objective To investigate the relationship between serum adipocyte fatty acid binding protein ( A-FABP) and interleukin 17 (IL-17) levels and lower extremity atherosclerotic disease (LEAD) in type 2 diabetes patients. Methods According to ankle-brachinal index, a total of 129 patients with type 2 diabetes mellitus were divided into diabetic lower extremity atherosclerotic disease ( LEAD) group (39 cases) and non-diabetic lower ex-tremity atherosclerotic disease ( NLEAD ) group (90 cases) . In addition, 40 cases of healthy persons were select-ed as control group ( NC group) . The serum levels of A-FABP and IL-17 were analysed and compared among three groups. Pearson correlation analysis were used to explore which factors influence on the serum level of A-FABP and IL-17. Logistic regression analysis were carried out to evaluate whether A-FABP and IL-17 were independent influ-encing factors of LEAD. Results Serum level of A-FABP and IL-17 were higher in NLEAD group than that in NC group, Serum level of A-FABP and IL-17 were higher in LEAD group than in NLEAD group (P＜0. 05). Pearson correlation analysis showed that the level of serum A-FABP was positively correlated with both body mass index, he-moglobin A1c, systolic blood pressure, homeostasis model assessment for insulin resistance, serum creatinine, and IL-17(r=0. 224, 0. 164, 0. 147, 0. 183, 0. 173, 0. 203, respectively, P＜0. 05). In addition, Pearson correla-tion analysis also showed that the level of serum IL-17 was positively correlated with both low density lipoprotein cholesterol (LDL-c), hemoglobin A1c and systolic blood pressure(r=0. 162, 0. 255, 0. 152,respectively, P ＜0. 05). Logistic analysis showed that LDL-c, serum A-FABP and IL-17 were independent risk factors for LEAD. Conclusion The levels of A-FABP and IL-17 are increased significantly in patients with type 2 diabetes lower ex-tremity atherosclerotic disease, and closely related to the development of LEAD.关键词
2型糖尿病/糖尿病周围血管病变/脂肪细胞型脂肪酸结合蛋白/白细胞介素-17Key words
type 2 diabetes mellitus/diabetic lower extremity atherosclerotic disease/adipocyte fatty acid binding protein/interleukin 17分类
医药卫生引用本文复制引用
刘玮,郑亚虹,沈颖,许慕蓉,万丽娟,陈明卫..血清脂肪细胞型脂肪酸结合蛋白和白细胞介素-17水平与2型糖尿病患者下肢动脉粥样硬化病变的相关性研究[J].安徽医科大学学报,2018,53(7):1085-1088,4.基金项目
安徽省卫生厅医学科研重点项目(编号:2010A008) （编号:2010A008）
