安徽医科大学学报2018，Vol.53Issue(7)：1126-1129,4.DOI:10.19405/j.cnki.issn1000-1492.2018.07.029
克罗恩病患者Hcy、sTM及PC水平改变的临床观察
Clinical observation of changes in Hcy, sTM and PC levels in Crohn's disease patients
摘要
Abstract
Objective To investigate the association between the serum levels of homocysteine ( Hcy) , soluble thrombomodulin ( sTM) and protein C ( PC) with the clinic characteristics in patients with Crohn's disease ( CD) . Methods 74 CD patients'clinical data in the first affiliated hospital of Anhui medical university were collected. The levels of Hcy, sTM and PC in CD patients were detected by ELISA, and the correlation analysis of them with clinic parameters were performed. Results The levels of Hcy and sTM in patients were significantly higher than those in the normal groups (P＜0. 01), the level of PC was slightly lower than normal control, the difference was not statistically significant. However, the levels of PC in the subgroup of non-stenotic with non-penetrating was sig-nificantly higher than that in the subgroup of stenosis(P＜0. 05). Moreover, the levels of sTM were positive related with PC levels in all the patients with CD, and the difference was statistically significant. Conclusion The levels of Hcy and sTM in CD patients were increasing and which indicated that possible high risk of thrombosis events in patients with CD.关键词
克罗恩病/同型半胱氨酸/血栓调节蛋白/蛋白CKey words
Crohn's disease/homocysteine/sTM/protein C分类
医药卫生引用本文复制引用
刘伟,王晶,丁少桢,胡翠,刘晓昌,梅俏,许建明..克罗恩病患者Hcy、sTM及PC水平改变的临床观察[J].安徽医科大学学报,2018,53(7):1126-1129,4.基金项目
国家自然科学基金(编号:81470809) （编号:81470809）
