北华大学学报（自然科学版）2018，Vol.19Issue(4)：487-490,4.DOI:10.11713/j.issn.1009-4822.2018.04.015
静脉应用氨甲环酸在椎体成形术治疗骨质疏松性椎体压缩性骨折中的安全性和有效性
Efficacy and Safety of Intravenous Injection of Tranexamic Acid in Percutaneous Vertebroplasty for the Treatment of Osteoporotic Vertebral Compression Fracture
摘要
Abstract
Objective To explore the efficacy and safety of intravenous injection of tranexamic acid ( TXA) during percutaneous vertebroplasty ( PVP ) in elderly patients with osteoporotic vertebral compression fracture. Method A total of 124 elderly patients undergoing PVP were divided into two groups according to the inclusion and exclusion criteria. There were 66 patients in TXA group and 58 patients in the control group. The primary outcomes were stroke, systemic embolism, bleeding and mortality. The secondary outcomes were incision infection,exudation, hematoma and hospital stay. Results For the outcome of bleeding, there was significant difference between TXA group and the control group. There were no notable differences between the two groups in the rates of stroke,systemic embolism and mortality. Similarly,there were significant differences between the two groups in the rates of incision infection,exudation,and hospital stay,but no significant difference was found in the rate of hematoma. Conclusion Elderly patients with osteoporotic vertebral compression fracture receiving TXA treatment during PVP exhibited a decline in the rates of incision infection,exudation and bleeding,and similar in the time of hospital stay. Furthermore,it did not increased the rate of stroke or systemic embolism.关键词
氨甲环酸/椎体成形术/骨质疏松性椎体压缩性骨折Key words
tranexamic acid/percutaneous vertebroplasty/osteoporotic vertebral compression fracture分类
医药卫生引用本文复制引用
郭海峰,陈钱,宋扬,郭建平..静脉应用氨甲环酸在椎体成形术治疗骨质疏松性椎体压缩性骨折中的安全性和有效性[J].北华大学学报（自然科学版）,2018,19(4):487-490,4.基金项目
吉林市卫生指导科技项目(201737161) （201737161）
吉林省科学技术研究项目(JJKH20170052KJ). （JJKH20170052KJ）
