川北医学院学报2018，Vol.33Issue(3)：369-372,4.DOI:10.3969/j.issn.1005-3697.2018.03.019
自体外周血干细胞移植联合介入治疗下肢动脉缺血性疾病的效果评价
Evaluation effect of autologous peripheral blood stem cell transplantation combined with interventional therapy in treatment of chronic lower limb is-chemia
摘要
Abstract
Objective:To investigate the autologous peripheral blood stem cell transplantation ( ABSCT) combined with inter-ventional therapy in treatment of chronic lower limb ischemia. Methods:38 patients with chronic lower limb ischemia were divided into 2 groups. 19 patients treated with ABSCT combined with interventional therapy were used as combined treatment group,and the other 19 patients treated with autologous peripheral blood stem cell transplantation and interventional as single interventional therapy group. The patients in two groups receieved conventional therapy. The limb pain, cold feeling, intermittent claudication, ankle brachial index (ABI) and the number of collateral vessel formation of the patients in two groups were observed before and after treatment,and the cur-ative effects in two groups were compared. Results:Compared with before treatment,the limb pain scores,cold feeling scores and inter-mittent claudication scores of the patients in two groups after treatment were significantly decreased,the differences were statistically sig-nificant (P＜0. 05),and the ABI and the number of collateral vessel formation were increased,and the difference was statistically sig-nificant (P＜0. 05). Compared with the intervention group,the limb pain,cold feeling,intermittent claudication,ABI and the number of collateral vessel formation of the patients in the combined treatment group were more significant (P＜0. 05). The total effective rate of the two groups were 89. 5% and 78. 9% ,respectively,the total effective rate in combinaed treatment group was higher than that in sin-gle interventional therapy group (P＜0. 05). Conclusion:ABSCT combined with interventional therapy is a safe and effective method for the treatment of chronic lower limb ischemia.关键词
下肢动脉缺血性疾病/干细胞移植/介入治疗Key words
Chronic lower limb ischemia/ABSCT/Interventional therapy分类
医药卫生引用本文复制引用
张瑞鹏,戴毅,王辉,张鸿,李伟,王小军..自体外周血干细胞移植联合介入治疗下肢动脉缺血性疾病的效果评价[J].川北医学院学报,2018,33(3):369-372,4.基金项目
陕西省科技攻关项目(2014K11-02-01-08) （2014K11-02-01-08）
