磁共振成像2018，Vol.9Issue(6)：406-410,5.DOI:10.12015/issn.1674-8034.2018.06.002
术前动态磁敏感对比增强MR灌注加权成像在脑胶质瘤预后评估中的价值研究
Prognostic value of preoperative dynamic susceptibility contrast-enhanced MR imaging in patients with gliomas
梁甜甜 1张辉 2王效春 2谭艳 2秦江波 2王乐 2张磊2
作者信息
- 1. 山西医科大学医学影像学系,太原030001
- 2. 山西医科大学第一医院影像科,太原 030001
- 折叠
摘要
Abstract
Objective:To investigate the relationship of maximum value of relative cerebral blood volume(rCBV)from dynamic susceptibility contrast-enhanced MRI(DSC-MRI)to prognosis in patients with gliomas.Materials and Methods: We conducted a retrospective analysis of the preoperative perfusion MR imaging in 62 histologically confirmed gliomas.Median relative CBV values were selected for quantitative analysis.Survival analysis was made by constructing survival curves using the Kaplan-Meier method with subgroups compared by Log-rank probability tests.A Cox regression model was made for multivariate analysis.Results: Kaplan-Meier survival curves demonstrated that overall survival of high rCBVmax(≥4.47)was significantly shorter than that of low rCBVmax(＜4.47)(P＜0.001),overall survival of low-grade glioma was significantly longer than that of high-grade glioma(P=0.001).Incooperating rCBVmaxand pathological grade,the prognosis was best for the group of LGG+rCBVmax＜4.47 and worst for the group of HGG+rCBVmax≥4.47.No significant difference was found between the group of LGG+rCBVmax≥4.47 and HGG+rCBVmax＜4.47(P=0.154).Multivariate analysis suggested that rCBVmax was associated with survival independent of pathology(P=0.001).Conclusions: The rCBVmaxvalue may be an independent indicator of prognosis in patients with glioma and an adjunct to WHO grading to determine clinical individual treatment.关键词
神经胶质瘤/灌注加权成像/磁共振成像/动态对比增强Key words
Glioma/Perfusion weighted imaging/Magnetic resonance imaging/Dynamic susceptibility contrast分类
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梁甜甜,张辉,王效春,谭艳,秦江波,王乐,张磊..术前动态磁敏感对比增强MR灌注加权成像在脑胶质瘤预后评估中的价值研究[J].磁共振成像,2018,9(6):406-410,5.
