早产儿与足月儿脑结构网络属性与模块化特征对比研究
Comparison of properties and module pattern of brain structural network between preterm and term neonates
摘要
Abstract
Objective:To compare the properties and module pattern of brain structural network between preterm and term neonates.Materials and Methods:20 preterm(gestational age,30—37 weeks)and 22 term neonates(gestational age,37—42 weeks)underwent 3D magnetic resonance T1-weighted imaging scan were recruited.All participants' brain was segmented into 122 regions by using neonatal brain anatomical atlas and 64 gray matter regions were selected to reconstruct the binary brain volume network.The network properties and module pattern were compared between the two groups.Results: The brain structural network of two groups possessed the small-world properties; in contrast to term neonates,preterm showed statistically decreased clustering coefficient and local efficiency(P＜0.05),and unorganized module pattern.Conclusions: The brain structural network of preterm and term neonates showed the small-world properties.The decreased information-transformation efficiency and unorganized module pattern may suggest the delay or abnormal development of inter-region information integration capacity in preterm neonates.关键词
早产儿/足月儿/脑容积/脑结构网络/模块化特征/磁共振成像Key words
Preterm neonates/Term infant/Brain volume/Brain structural network/Module pattern/Magnetic resonance imaging分类
医药卫生引用本文复制引用
金超,杨健,胡亚杰,李贤军,王苗苗,李彦彦,程燕南,王小玗,陶星星,赵慧芳..早产儿与足月儿脑结构网络属性与模块化特征对比研究[J].磁共振成像,2018,9(6):411-416,6.基金项目
国家重点研发计划项目(编号:2016YFC0100300) （编号:2016YFC0100300）
国家自然科学基金面上项目(编号:81471631,81771810,51706178) （编号:81471631,81771810,51706178）
2011年教育部"新世纪优秀人才支持计划"(编号:NCET-11-0438) （编号:NCET-11-0438）
中国博士后科学基金面上项目(编号:2017M613145) （编号:2017M613145）
陕西省自然科学基金青年项目(编号:2017JQ8005) （编号:2017JQ8005）
西安交通大学第一附属医院临床研究课题重点项目(编号:XJTU1AF-CRF-2015-004).This work was part of National Key Research and Development Program of China (No.2016YFC0100300) （编号:XJTU1AF-CRF-2015-004）
National Natural Science Foundation of China (No.81471631,81771810 and 51706178) （No.81471631,81771810 and 51706178）
2011 New Century Excellent Talent Support Plan of the Ministry of Education,China (No.NCET-11-0438) （No.NCET-11-0438）
China Postdoctoral Science Foundation (No.2017M613145) （No.2017M613145）
Shaanxi Provincial Natural Science Foundation for Youths of China (No.2017JQ8005) and Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University (No.XJTU1AF-CRF-2015-004). （No.2017JQ8005）
