磁共振成像2018，Vol.9Issue(6)：460-464,5.DOI:10.12015/issn.1674-8034.2018.06.011
ADC值在原发性脑淋巴瘤放疗疗效中的预测价值
Predictive value of ADC value in radiotherapy of primary brain lymphoma
摘要
Abstract
Objective:To investigate the predictive value of pretherapeutic apparent diffusion coefficient(ADC)value in the diffusion-weighted imaging for radiotherapy of primary brain lymphoma.Materials and Methods: 20 patients,from 2009 to 2017,in General Hospital of Ningxia Medical University clinical examination without history of immunodeficiency disease were collected,which were clinically and biopsy confirmed as diffuse large B cell lymphoma.The maximum diameter of enhanced lesion were measured from axial enhanced T1WI,before and after the radiotherapy,via which the tumor regression rate can be calculated.Then the primary brain lymphoma can be divided into two groups,called as complete remission(CR)group and non-complete remission(non-CR)group,via tumor regression rate.The minimum ADC(ADCmin)value,the average ADC(ADCmean)value,the maximum ADC(ADCmax)value of the lesion before radiotherapy were measured,the various ADC value in two groups were analyzed using statistical approach.Results: The difference between ADCmin value and ADCmean value before radiotherapy was statistically significant(P＜0.05)between CR group and non-CR group,while ADCmaxvalue had no significant difference between the two groups.ADCminvalue and ADCmeanvalue correlated with tumor regression rate,while each value were greater than 0.602×10-3mm2/s,0.800×10-3mm2/s,the patients can be achieved CR effect after the completion of the radiotherapy cycle.Conclusions: ADCminvalue and ADCmeanvalue can be used as imaging biomarkers to predict the radiotherapy efficacy of the primary brain lymphoma.关键词
脑/淋巴瘤/表观扩散系数/放疗/磁共振成像Key words
Brain/Lymphoma/Apparent diffusion coefficient/Radiotherapy/Magnetic resonance imaging分类
医药卫生引用本文复制引用
师达,石亚男,詹文华,杨旭娟,张攀,李健,徐梦莹,陈兵..ADC值在原发性脑淋巴瘤放疗疗效中的预测价值[J].磁共振成像,2018,9(6):460-464,5.基金项目
宁夏自然科学基金(编号:NZ15146).This work was part of Ningxia Natural Science Foundation (No.NZ15146). （编号:NZ15146）
