动物医学进展2018，Vol.39Issue(7)：74-80,7.
TGF-β通路与哺乳动物卵母细胞发育研究进展
Progress on TGF-β Signal Way and Mammalian Oocyte Development
摘要
Abstract
The transforming growth factor β(TGF-β)signal way is a large family of multi-functional cyto-kines which include many members.Numerous studies have shown that they play an important role in oo-cyte formation and development.TGF-β signal way plays its function mainly through the binding comple-xes of ligand and receptor,and then they activate the relevant molecules regulating the expression of cruci-al genes of oocyte development.This series of processes are divided into two branches which include the direct function like bone morphogenetic proteins (BMPs),activins,inhibins,TGF-βs and anti-Mullerian hormone (AMH),besides,the indirect function is impacted by the three main routes of cAMP,hormones and epidermal growth factor (EGF).This article summarized the research progress on the influence of TGF-β pathway on mammalian oocyte development,which lays a theoretical foundation for further rele-vant research.关键词
转化生长因子β/卵母细胞/环磷酸腺苷Key words
TGF-β/oocyte/cAMP分类
农业科技引用本文复制引用
牛慧敏,王丽丽,张俊玉,吕珊,尚江华,雷安民..TGF-β通路与哺乳动物卵母细胞发育研究进展[J].动物医学进展,2018,39(7):74-80,7.基金项目
抗病高产转基因猪新品种培育(2016ZX08006-003) （2016ZX08006-003）
广西水牛遗传繁育重点实验室开放课题(SNKF-2012-01) （SNKF-2012-01）
