腹腔镜外科杂志2018，Vol.23Issue(5)：353-356,4.DOI:10.13499/j.cnki.fqjwkzz.2018.05.353
腹腔镜联合同步新辅助放化疗治疗中低位局部进展期直肠癌的疗效观察
Clinical observation of laparoscopy combined with neoadjuvant chemoradiotherapy for middle and low locally advanced rectal cancer
摘要
Abstract
Objective:To investigate the clinical effect of laparoscopy combined with neoadjuvant chemoradiotherapy for middle and low locally advanced rectal cancer.Methods:A total of 84 patients with middle and low locally advanced rectal cancer from Jan. 2012 to Feb.2015 were selected as the objective of this study.The patients were divided into the observation group and the control group according to the random number table method ,there were 42 cases in each group.The patients in the control group were treated with open radical resection of rectal cancer ,the observation group was treated with neoadjuvant chemoradiotherapy and laparoscopic radical resection of rectal cancer.The 2 groups were followed up for at least 2 years.The intraoperative conditions ,immune function and postop－erative complications of the 2 groups were recorded and compared.Results:The operation time of the observation group was significantly longer than that of the control group ,the amount of bleeding during operation ,hospitalization time,feeding time and the recovery time of intestinal function were significantly less than those of the control group (P＜0.05),there was no significant difference in the number of dissected lymph node between the two groups (P＞0.05).After 1 day to 7 days,the CD3+,CD4+and CD8+of 2 groups were decreased first and then increased (P＜0.05);On the first day after operation,the levels of CD4+and CD8+in the observation group were signifi－cantly higher than those in the control group ,and the levels of CD3+and CD8+after 7 days of the operation were significantly higher than those of the control group (P＜0.05).The incidence of total complications and adhesive intestinal obstruction in the observation group was significantly less than that in the control group (P＜0.05).Conclusions:Laparoscopy combined with concurrent neoadjuvant chemoradiotherapy is superior to traditional treatment for locally advanced rectal cancer .It is beneficial for the recovery of immune sys－tem and has fewer complications ,and is worthy of clinical application.关键词
直肠肿瘤/腹腔镜检查/新辅助放化疗/治疗结果Key words
Rectal neoplasms/Laparoscopy/Neoadjuvant radiochemotherapy/Treatment outcome分类
医药卫生引用本文复制引用
杨国华,秦长江,刘培杰..腹腔镜联合同步新辅助放化疗治疗中低位局部进展期直肠癌的疗效观察[J].腹腔镜外科杂志,2018,23(5):353-356,4.基金项目
河南省医学科技攻关计划项目(编号:201601029) （编号:201601029）
