广东医学2018，Vol.39Issue(8)：1154-1158,5.
非小细胞肺癌中循环肿瘤细胞与Ki-67的相关性
Correlation between circulating tumor cells and Ki-67 in non-small cell lung cancer
摘要
Abstract
Objective To investigate the correlation between circulating tumor cell (CTCs) and Ki-67 expres-sion or clinicopathological parameters in non -small cell lung cancer (NSCLC).Methods The CTCs in blood was sepa-rated by CanPatrolTMCTC enrichment technique .The expression of Ki -67 in surgical specimens was analyzed by immu-nohistochemistry.The correlation between CTCs and Ki -67 was analyzed.Results The positive rate of CTCs in 75 pa-tients with NSCLC was 92%.The positive rate of interstitial CTCs were 30.1%, 42.9%, 50.0%and 66.7%in StageⅠ(n＝26), Stage Ⅱ(n＝21), Stage Ⅲ(n＝22) and Stage Ⅳ(n＝6) NSCLC, respectively.At Stage Ⅲ and Ⅳ, the positive rate of CTCs was significantly higher than that at Stage ⅠandⅡ(χ2＝4.265, P＝0.039).The positive rate of CTCs was significantly different between those with lymph node metastasis and without lymph node metastasis ( χ2＝4.904, P＝0.027).The positive rate of interstitial CTCs was increased with the progression of NSCLC .There was no sig-nificant difference in Ki -67 index or interstitial CTCs positive rate among genders , ages, pathologic types or differentia-tions (P＞0.05).The positive rate of interstitial CTCs in Ki -67 high expression group was 55.1%(27/49), which was significantly higher than that in Ki -67 low expression group (30.8%, 8/26) (χ2＝4.041, P＝0.044).Conclusion In CTCs, the positive rate of interstitial CTCs increases with progression of NSCLC , and the Ki-67 expression is closely correlated to the positive rate of interstitial CTCs .关键词
非小细胞肺癌/循环肿瘤细胞/Ki-67Key words
non-small cell lung cancer/circulating tumor cells/Ki-67引用本文复制引用
郑乔瑞,谭翔,王永勇,戴磊,梁冠标,陈铭伍..非小细胞肺癌中循环肿瘤细胞与Ki-67的相关性[J].广东医学,2018,39(8):1154-1158,5.基金项目
国家自然科学基金资助项目(编号:81660387) （编号:81660387）
