广东医学2018，Vol.39Issue(12)：1830-1835,6.
大肠埃希菌碳青霉烯异质性耐药分析及流行病学调查
Epidemiology and heterogeneous drug resistance of Escherichia coli
摘要
Abstract
Objective To investigate the epidemiological characteristics of carbapenenems heteroresistant Esche-richia coli (CHEC) and the risk factors of infections , so as to provides theoretical basis for the rational application of anti-microbial agents.Methods The Escherichia strains isolated from clinical specimens were collected.The extended －spectrum－lactamase (ESBL)－producing isolates was tested.PAP assay was performed.The drug resistance spectrum was analyzed so as to confirm the independent risk factors for the heterogeneity resistance of E.coli.Results The 200 strains of Escherichia coli were mainly separated from blood , urine and sputum, and the detection rates were 29.5%, 16.5%and 15.0%, respectively.The rates of resistant heterogeneity were 6.0%to meropenem (MEM), 20.5%to er-tapenem (ETP) and 29.0%to imipenem (IMP).The major risk factors were production of extendedspectrumbeta －lacta-mases (ESBLs), the surgery department, previous antibiotic use and invasive operations (P＜0.05).Conclusion The carbapenems heteroresistant heterogeneity in Escherichia coli is very serious.In particular, ESBLs, surgical ward, antibi-otic use and invasive medical operations are related to the heterogeneity of carbon penicilliene .关键词
大肠埃希菌/碳青霉烯耐药/异质性耐药/危险因素Key words
escherichia coli/carbapenems resistant/heteroresistant/risk factor引用本文复制引用
张文萍,张秋萍,崔海燕,李爱敏,叶飞娣,黄莎莎,崔成华,单万水..大肠埃希菌碳青霉烯异质性耐药分析及流行病学调查[J].广东医学,2018,39(12):1830-1835,6.基金项目
深圳市知识创新计划项目(编号:JCYJ20150402111430615) ,深圳市三名工程项目(编号:SZSM201412005) （编号:JCYJ20150402111430615）
