广东药科大学学报2018，Vol.34Issue(3)：265-270,6.DOI:10.16809/j.cnki.2096-3653.2018031301
羟基喜树碱长循环纳米粒的药动学与组织分布研究
Study on pharmacokinetics and tissue distribution of hydroxycamptothecine long-circulation nanoparticles
摘要
Abstract
Objective To study the pharmacokinetics and tissue distribution of hydroxycampylocine ( HCPT) long-circulation nanoparticles. Methods After tail vein injection, the blood was collected from eye socket and the mice organs were removed. The concentration of HCPT was determined to calculate HCPT long circulating nanoparticles pharmacokinetic parameters of HCPT long circulating nanoparticles in rats with normal HCPT nanoparticles and HCPT solution as comparison groups respectively and changes of HCPT concentration in mice. Results The process in rats of HCPT long-circulation nanoparticles conformed to two-compartment model. The highest concentration of HCPT long-circulation nanoparticles was obtained with 63.11 μg/mL in liver, while the concentration in heart was only 1.01 μg/mL. The sequence of HCPT levels in different tissues was: liver>lung> spleen>kidney>heart. Conclusion Compared with HCPT conventional nanoparticles and solution, HCPT long-circulation nanoparticles can significantly improve HCPT bioavailability, prolong its retention time in vivo and form significant liver targeting.关键词
羟基喜树碱/长循环纳米粒/药动学/组织分布Key words
hydroxycamptothecine/long-circulation nanoparticles/pharmacokinetics/tissue distribution分类
医药卫生引用本文复制引用
蒋梦玥,王彦苏,杜妍旖,黄明月,李木生,刘晓芳,王婴,王岩..羟基喜树碱长循环纳米粒的药动学与组织分布研究[J].广东药科大学学报,2018,34(3):265-270,6.基金项目
国家自然科学基金资助项目(81673608) （81673608）
广东省科技计划项目(2015A020211034,2014A020212685) （2015A020211034,2014A020212685）
广州市科技计划项目(201707010155) （201707010155）
广东省大学生科技创新培养专项基金(Pdjh2017b0268) （Pdjh2017b0268）
