广东药科大学学报2018，Vol.34Issue(3)：312-315,4.DOI:10.16809/j.cnki.2096-3653.2018030501
天南星科有毒中药及其炮制品的急性毒性试验研究
Acute toxicity study on Araceae toxic herbs and its processed products
摘要
Abstract
Objective To study the acute toxicity of three Araceae toxic Chinese herbs and their processed products, including pinelliae rhizoma, arisaematis rhizoma and typhonii rhizome. Methods The experiments were designed according to Bliss algorithm, and mice were injected intraperitoneally with aqueous extract of Chinese herbs, and continuously observed for 14 days. The LD50of pinelliae rhizoma, arisaematis rhizoma and typhonii rhizoma were calculated with acute mortality. Results The LD50of pinelliae rhizoma, arisaematis rhizoma and typhonii rhizoma were 5. 381 g/kg, 21. 508 g/kg, 39. 311 g/kg, respectively, but their processed products had no significant toxicity. Conclusion Three Araceae toxic Chinese herbs including pinelliae rhizoma, arisaematis rhizoma and typhonii rhizoma have significant acute toxicity, among which the toxicity of pinelliae rhizoma is the strongest, but the toxin could be reduced significantly after being processed.关键词
半夏/天南星/白附子/急性毒性/LD50Key words
pinelliae rhizoma/arisaematis rhizoma/typhonii rhizoma/acute toxicity/LD50分类
医药卫生引用本文复制引用
吴紫君,冯碧川,沈志滨,杨超燕,陈嘉洛,彭昌杰,吴志坚,李书渊,陈艳芬..天南星科有毒中药及其炮制品的急性毒性试验研究[J].广东药科大学学报,2018,34(3):312-315,4.基金项目
广东药科大学2015级省级大学生创新创业训练计划项目(201510573034) （201510573034）
国家中医药管理局中医药行业专项(201507004) （201507004）
