广东药科大学学报2018，Vol.34Issue(3)：325-329,5.DOI:10.16809/j.cnki.2096-3653.2018010201
束花石斛提取物对糖尿病模型大鼠血糖血脂的影响
Effect of Dendrobium chrysanthum Lindl. total extract on the blood glucose and blood lipids in diabetic rats
摘要
Abstract
Objective To investigate the effect of ethanolic extract from Dendrobium chrysanthum Lindl.( D. chrysanthum) on the blood glucose and blood lipids in diabetic rats. Methods Type 2 diabetes mellitus rats were induced by intraperitoneal injection of 35 mg/kg streptozotocin ( STZ) and a high-carbohydrate/high-fat diet. Diabetic rats were randomly divided into four groups: the model group ( 5 mL/kg physiological saline) , the positive control ( 0.42 mg/kg rosiglitazone) , the low-dose group ( 1.08 g/kg D.chrysanthum) , and the high-dose group ( 2.16 g/kg D.chrysanthum) .The blood glucose and body weight were recorded. After treatment for 8 weeks, the serum TG, TC, HDL-C, LDL-C, GSP, insulin and OGTT were measured. The insulin resistance ( IR) index was calculated. Results Compared with the model group, the blood glucose in the high-dose group was decreased by 40.6% than before administration.The contents of TC, TG and LDL-C were significantly decreased ( P<0.05) , and HDL-C was increased in the high-dose group.The contents of TG and LDL-C were significantly lowered ( P<0.05) , and HDL-C were increased in the low-dose group. Compared with the model group, the blood glucose, GSP and insulin resistance index were significantly lowered in administration groups. Meantime, the insulin level was increased and OGTT was improved. Conclusion D.chrysanthum could significantly improve the glucose and lipid metabolic disorder in T2DM rats in a dose-dependent manner.关键词
2型糖尿病/束花石斛/血糖/血脂Key words
T2DM/D.chrysanthum/blood glucose/blood lipids分类
医药卫生引用本文复制引用
杨超,林伟龙,蔡金艳..束花石斛提取物对糖尿病模型大鼠血糖血脂的影响[J].广东药科大学学报,2018,34(3):325-329,5.基金项目
广州市珠江科技新星专项(201506010061) （201506010061）
2015年广东省高等学校优秀青年教师培养计划资助项目(YQ2015097) （YQ2015097）
