国际老年医学杂志2018，Vol.39Issue(3)：104-106,114,4.DOI:10.3969/j.issn.1674-7593.2018.03.002
脑苷肌肽辅助治疗老年急性脑梗死的临床研究
Effects of Adjuvant Treatment of Cattle Encephalon Glycoside and Ignotin on Acute Cerebral Infarction in Elderly Patients
冯远 1陈光学1
作者信息
- 1. 湖北省大冶市人民医院神经内科, 大冶 435100 中国
- 折叠
摘要
Abstract
Objective To investigate the effect of cattle encephalon glycoside and ignotin injection on the blood-brain bar-rier, neurological function and incidence of brain edema in patients with acute cerebral infarction.Methods 80 patients with acute cerebral infarction were divided into the control group and the observation group according to random number table.Both groups were given conventional treatment, and the observation group was additionally treated with cattle encephalon glycoside and ignotin injection.After 2 weeks of treatment, serum levels of MMP-7, MMP-8 and S100B were measured to determine the integrity of blood-brain barrier.NIHSS and QOL100 scale were used to evaluate the neurological function and quality of life.CT scan was performed to detect the cerebral edema.Results The overall response rate in the observation group was higher than that in the control group (P <0.05).The levels of MMP-7, MMP-8 and S100B after treatment were lower than those before treatment, and the levels in the ob-servation group was significant lower than those in the control group (P<0.05).NIHSS scores were significantly decreased (P<0.05), while QOL100 scores were significantly increased after treatment than those before treatment (P <0.05), the changes of scores in the observation group were more significant than those in the control group (P<0.05).The incidence rate of cerebral edema in the observation group was lower than that in the control group (P<0.05).Conclusion The application of conventional therapy combined with cattle encephalon glycoside and ignotin injection can improve neurological function, relieve cerebral edema and protect blood-brain barrier in patients with acute cerebral infarction.关键词
急性脑梗死/脑苷肌肽/神经功能/脑水肿Key words
Acute cerebral infarction/Cattle encephalon glycoside and ignotin/Neurological function/Cerebral edema引用本文复制引用
冯远,陈光学..脑苷肌肽辅助治疗老年急性脑梗死的临床研究[J].国际老年医学杂志,2018,39(3):104-106,114,4.
