国际妇产科学杂志2018，Vol.45Issue(3)：327-330,4.
卵巢癌中雷公藤内脂醇的研究进展
Progress of Triptolide in Ovarian Cancer
摘要
Abstract
Ovarian cancer is a serious threat to women's reproductive health, and the mortality is the first of various gynecological tumors. Multidrug resistance (MDR) is a major cause of post-treatment relapses, metastasis, and even death. The role of triptolide (TP) in the treatment of ovarian cancer has attracted much attention, especially in the treatment of MDR in ovarian cancer. In this review, the mechanism of TP on ovarian cancer is reviewed in the two aspects of inhibiting the proliferation and inducing the apoptosis of tumor cells. The toxicity of TP and the short half-life have limited the clinical application. However,the emergence of nano-drug delivery technology has provided a broader prospect for the treatment of ovarian cancer by TP.关键词
雷公藤内酯/卵巢肿瘤/抗药性,多药/细胞凋亡/细胞增殖Key words
Triptolide/ Ovarian neoplasms/ Drug resistance, multiple/ Apoptosis/ Cell proliferation引用本文复制引用
杜秋越,申彦..卵巢癌中雷公藤内脂醇的研究进展[J].国际妇产科学杂志,2018,45(3):327-330,4.基金项目
天津市卫生局科技基金(2014KR20) （2014KR20）
