临床与病理杂志2018，Vol.38Issue(1)：1-4,4.DOI:10.3978/j.issn.2095-6959.2018.01.001
姜黄素对肠缺血再灌注继发性肺损伤大鼠TNF-α与IL-6表达的影响
Effects of curcumin pretreatment on TNF-α and IL-6 during lung injury induced by intestinal ischemia-reperfusion in rats
摘要
Abstract
Objective: To evaluate the effects of curcumin pretreatment on TNF-a and IL-6 during lung injury induced by intestinal ischemia-reperfusion in rats. Methods: Thirty female healthy SD rats were divided into three groups randomly (n=10): sham operation group (S group), lung injury inducing by intestinal ischemia-reperfusion group (I/R group), curcumin pretreatment group (CUR group). In CUR group, rats were treated intragastrically with curcumin at a dose of 200 mg/kg for 5 d before operation while rats were treated intragastrically with the same volume of NS in S group and I/R group. Lung injury induced by intestinal ischemia-reperfusion in rats was conducted by clamping the superior mesenteric artery for 75 min. The rats were sacrificed after 4-h reperfusion. The lung tissues were obtained for pathological analysis, lung water content evaluation and the determination of TNF-a and IL-6 levels. Results: The pathological scores, lung water content, and the levels of TNF-a and IL-6 were significantly increased in group I/R and group CUR as compared with group S (P＜0.05). The pathological scores, lung water content, and the levels of TNF-a and IL-6 were significantly decreased in CUR group as compared with group I/R (P＜0.05). Conclusion: Curcumin pretreatment attenuates the lung injury induced by intestinal ischemia-reperfusion on rats, which might be associated with inhibition of the levels of TNF-a and IL-6 in lung tissue.关键词
姜黄素/肺损伤/缺血再灌注/肿瘤坏死因子a/白介素6Key words
curcumin/lung injury/ischemia reperfusion/TNF-a/IL-6引用本文复制引用
廖美娟,赵伟成,梁幸甜,贺俭,刘洪珍,王靖,肖蔚..姜黄素对肠缺血再灌注继发性肺损伤大鼠TNF-α与IL-6表达的影响[J].临床与病理杂志,2018,38(1):1-4,4.基金项目
佛山市卫生和计划生育局医学科研课题(20160083).This work was supported by the Medical Scientific Project Foundation ofFoshan Department of Health and Family Planning Bureau, China (20160083). （20160083）
