临床与病理杂志2018，Vol.38Issue(1)：12-15,4.DOI:10.3978/j.issn.2095-6959.2018.01.003
结肠癌中miR-1231表达变化的临床意义
Clinical significance of changing in miR-1231 expression in colon cancer
摘要
Abstract
Objective: To detect miR-1231 expression in colon cancer and explore its clinical significance. Methods: Ninetyfour patients of colon cancer were enrolled in this study. The non-cancerous tissues beside the tumor were taken as controls. QRT-PCR analysis was used to detect miR-1231 expression. Results: MiR-1231 expression in the colon cancer tissue was 0.146±0.018, which was lower than that of 0.282±0.047 in the control tissue (P＜0.01). There was no significant correlation of miR-1231 with colon cancer patients' gender, age, tumor location, and tumor size (P＞0.05). MiR-1231 expression in III and IV stage group was 0.125±0.014, which was lower than that of 0.161±0.028 in I and II stage group (P＜0.05). MiR-1231 expression in median and low differentiation group was 0.131±0.015, which was lower than that of 0.174±0.032 in well differentiation group (P＜0.05). MiR-1231 expression in lymph node metastasis group was 0.125±0.014, which was lower than that of 0.154±0.020 in nonlymph node metastasis group (P＜0.05). Pearson correlation analysis showed that the expression of miR-1231 was negatively correlated with clinical TNM analysis (r=-0.361, P＜0.05), tumor differentiation (r=-0.342, P＜0.05), lymph node metastasis (r=-0.354, P＜0.05). Conclusion: Low expression of miR-1231 is found in colon cancer, which may be related to clinical stages, lymph node metastasis, and tumor differentiation of bladder cancer.关键词
结肠癌/miR-1231/qRT-PCRKey words
colon cancer/miR-1231/qRT-PCR引用本文复制引用
顾园,龚攀..结肠癌中miR-1231表达变化的临床意义[J].临床与病理杂志,2018,38(1):12-15,4.基金项目
湖北省卫生和计划生育委员会2015-2016年度科研立项基金一般项目(2015MB180).This work was supported by the Project of Hubei Provincial 2015-2016 Health and Family Planning Commission of Science and Research Fund, China (2015MB180). （2015MB180）
