临床与病理杂志2018，Vol.38Issue(1)：16-22,7.DOI:10.3978/j.issn.2095-6959.2018.01.004
Kankl基因在食管鳞状细胞癌的表达
Kank 1 gene expression in esophageal squamous cell carcinoma
摘要
Abstract
Objective: To investigate the Kankl expression levels in esophageal squamous cell carcinoma (ESCC) and its relationship with clinicopathological data. Methods: Immunohistochemistry and real-time quantitative PCR(qRT-PCR) were used to detect the expression of Kankl protein and mRNA in 63 cases of esophageal squamous cell carcinoma (ESCC) and corresponding adjacent tissues, respectively. The correlation between Kankl and the dinicopathologic parameters of ESCC was statistically analyzed. Results: The positive expression rate of Kankl protein was 95％ in normal tissues, and its positive expression rate in ESCC tissues was 20％. The expression of Kankl in ESCC tissues was significantly lower than that in normal tissues (P＜0.05). The expression of Kankl mRNA was significantly different in normal esophageal tissues and squamous cell carcinoma. In addition, the Kanklexpression was significantly associated with tumor differentiation. However, Kankl protein and mRNA had no association with gender, ethnicity, age, tumor size, lymph node metastasis. Conclusion: The Kankl expression levels decrease in ESCC and normal tissues, suggesting that Kankl is a potential tumor suppressor of ESCC.关键词
食管鳞癌/Kankl/抑癌基因Key words
esophageal squamous cell carcinoma/Kankl/tumor suppressor gene引用本文复制引用
王玻玮,王雯,马方婧,马遇庆..Kankl基因在食管鳞状细胞癌的表达[J].临床与病理杂志,2018,38(1):16-22,7.基金项目
新疆医科大学第一附属医院青年科学基金(2014ZRQN20).This work was supported by Youth Science Project Foundation of First Affiliated Hospital of Xinjiang Medical University, China (2014ZRQN20). （2014ZRQN20）
