临床与病理杂志2018，Vol.38Issue(1)：35-39,5.DOI:10.3978/j.issn.2095-6959.2018.01.007
创伤性颅脑损伤患者中降钙素原、CRP及D-二聚体的临床检测意义
Clinical detection significance of procalctonin, CRP and D-dimer in traumatic brain injury patients
缪惠锴 1王嘉妮 2刘璐 2肖立2
作者信息
- 1. 南京医科大学附属无锡第二医院检验科,江苏 无锡 214002
- 2. 解放军第101医院检验科,江苏 无锡 214044
- 折叠
摘要
Abstract
Objective: To analyze the effects of procalcitonin (PCT), CRP, D-dimer on the severity and clinical prognosis of patients with traumatic brain injury (TBI). Methods: A total of 250 TBI patients were recruited from January2014 to December 2016, and the disease severity was assessed by Glasgow Coma Scale (GCS) score. Levels of PCT, CRP and D-dimer were detected and their co-relationship with patient's condition and death rate were investigated, and the Cox review model was used to explore the relationship with the patient's death. Results: Level of PCT, CRP and D-dimer in TBI patients increased significantly with the severity of the lesion; the level of GCS score of patients in the survival group elevated significantly when compared with that in the death group, whereas the levels of PCT, CRP and D-dimer in the survival group decreased significantly. Multivariate analysis indicated that PCT, CRP, D-dimer and GCS score were independent risk factors for death in TBI patients. The levels ofPCT, CRP and D-dimer were positive with GCS(r=-0.23;-0.32;-0.42; P＜0.05). Conclusion: Level of PCT, CRP and D-dimer closely associated with the severity and prognosis of TBI patients.关键词
降钙素原/CRP/D-二聚体/创伤性颅脑损伤Key words
procalcitonin/C reaction protein/D-dimer/traumatic brain injury引用本文复制引用
缪惠锴,王嘉妮,刘璐,肖立..创伤性颅脑损伤患者中降钙素原、CRP及D-二聚体的临床检测意义[J].临床与病理杂志,2018,38(1):35-39,5.
