临床与病理杂志2018，Vol.38Issue(1)：40-46,7.DOI:10.3978/j.issn.2095-6959.2018.01.008
mTOR基因rs2295079和rs2295080位点多态性与川崎病的关联性
Association between single nucleotide polymorphism rs2295080 and rs2295080 in mTOR gene and Kawasaki disease
摘要
Abstract
Objective: To investigate the association of single nucleotide polymorphism (SNP) of loci rs2295079(G>C) and rs2295080(C>A) in mammalian target of rapamycin (mTOR) gene with the susceptibility of Kawasaki disease(KD) and coronary artery lesion (CAL). Methods: A case-control study was performed by recruitment of 100 children with KD (KD group) and 100 healthy children (control group) as controls. In the KD group, there were 20 children with CAL (KD-CAL group) and 80 children without CAL (KD-WO group). Genotypes of these two SNP were detected and analyzed. Results: No significant difference was found in the frequency distribution of allele and genotype of SNP of loci rs2295079 (G>C) and rs2295080 (C>A) between the KD group and controls, the KD-CAL group and KD-WO group. Conclusion: No association is found between SNP of loci rs2295079(G>C) and rs2295080 (C>A) in mTOR gene and the development of KD.关键词
川崎病/mTOR基因/单核苷酸多态性Key words
Kawasaki disease/mTOR gene/single nucleotide polymorphism引用本文复制引用
刘锐,罗颉,查鹭婷,钱玉洁,刘欣,杨作成..mTOR基因rs2295079和rs2295080位点多态性与川崎病的关联性[J].临床与病理杂志,2018,38(1):40-46,7.基金项目
中南大学湘雅三医院新湘雅人才工程(20150312).This work was supported by the New Xiangya Talent Project of The Third Xiangya Hospital, Central South University, China (20150312). （20150312）
