临床与病理杂志2018，Vol.38Issue(1)：108-113,6.DOI:10.3978/j.issn.2095-6959.2018.01.019
高压氧对糖尿病足溃疡患者创面愈合、生活质量及负性情绪的影响
Effect of hyperbaric oxygen on wound healing, quality of life and negative emotion in patients with diabetic foot ulcers
摘要
Abstract
Objective: To observe the effect of hyperbaric oxygen (HBO) on wound healing, quality of life and negative emotion in patients with diabetic foot ulcers (DFUs). Methods: From January 2016 to May 2017, 60 patients with chronic DFUs were prospectively divided into the HBO group and the control group according to the random number table, 30 cases in each group. The control group received conventional treatment and nursing intervention. The HBO group was given HBO treatment. A period of compression is in air for 20 min, followed by a treatment period at 0.2 MPa for 65 min which contains oxygen uptake 60 min, and then a decompression period of 20 min. Each session of HBO treatment lasted 105 min. One times a day, 10 days for a course of treatment. After two consecutive treatment courses, the patient rested for 7-10 days,and then the 3-4 course of treatment were given. A total of 4 treatment courses were taken. On the basis of conventional treatment and nursing intervention, the wound severity was assessed by Wagner classification method. The quality of life was assessed using the concise Health Questionnaire (SF-36). The Hamilton anxiety scale (HAMA) was used to assess the anxiety status. Results: The HBO group completed four courses of intervention successfully, and no HBO related complications were found. After the intervention, the Wagner grade of wound severity was reduced in the HBO group compared with the control group(the I, II,III, IV were 2, 5, 10, 3 cases in the HBO group, and 2, 10, 13, 5 respectively in the control group, χ2=9.701, P=0.021). The role limitation due to physical health scale(66.5±10.7 vs 57.8±8.9, t=3.424,P=0.00l), the bodily pain(60.8±8.7 vs 55.6±4.9, t=2.852, P=0.006) and the role limitation due to mental health(72.8±6.5 vs 68.9±5.6, t=2.490,P=0.016) of SF-36 were significantly improved in the HBO group. The HAMA anxiety scale score was lower in the HBO group(7.6±3.4 vs 11.2±5.5, t=3.049, P=0.003). Conclusion: HBO therapy can effectively promote wound healing, improve the quality of life and relieve anxiety symptoms in DFUs patients.关键词
高压氧/糖尿病足/足溃疡/生活质量/焦虑Key words
hyperbaric oxygen/diabetic foot/foot ulcer/quality of life/anxiety引用本文复制引用
蒋丽艳,周苏键,刘文玉..高压氧对糖尿病足溃疡患者创面愈合、生活质量及负性情绪的影响[J].临床与病理杂志,2018,38(1):108-113,6.基金项目
福建省自然科学基金(09J01186).This work was supported by Fujian Provincial Natural Science Foundation, China(09J01186). （09J01186）
