临床与病理杂志2018，Vol.38Issue(1)：147-155,9.DOI:10.3978/j.issn.2095-6959.2018.01.025
P53蛋白在葡萄胎中表达的Meta分析
Expression of P53 protein in hydatidiform mole: A Meta-analysis
张蕾 1赵丹丹 1李家平 1朱园园 1沈乾坤 1何涛1
作者信息
- 1. 河南科技大学临床医学院,河南科技大学第一附属医院妇产科,河南 洛阳 471003
- 折叠
摘要
Abstract
Objective: To systematically review the expression of P53 protein in hydatidiform mole and its differential diagnosis. Methods: Relevant literature sources were searched using databases from the inception to May 1,2017 including Pubmed,Medline, Embase, CNKI, Wanfang Data, VIP and CBM, and the related references were traced. RevMan 5.3 was used for our Meta-analysis, and Begg's and Egger's were used to analyze possible publication bias. Results: A total of 18 studies involving 436 complete hydatidiform mole (CHM), 369 partial hydatidiform mole (PHM) and 220 hydropic abortus (HA) were included. The expression of P53 in CHM group was significantly higher than that of PHM group(OR =2.84, 95％ CI 2.00-4.04, P＜0.001); but the subgroup analysis showed: there was no significant expression between CHM group and PHM group in Europe (OR =0.55,95％ CI 0.16-1.85, P=0.33); in Asians, the expression of P53 in CHM group was significantly higher than that ofPHM group(OR =336, 95％ CI 2.31-4.88, P＜0.001); the positive rate of P53 in CHM and PHM group were significantly higher than those of hydropic abortion group(OR =32.15; 95％ CI 18.97-54.49, P＜0.001; OR =13.11, 95％ CI 8.21-20.93, P＜0.001). Conclusion: Current evidence shows that the high expression of P53 may play an important role in the genesis and development of hydatidiform mole, which can provide a reference for the early diagnosis and treatment of hydatidiform mole.关键词
葡萄胎/P53蛋白/Meta分析/病例-对照研究Key words
hydatidiform mole/P53 protein/Meta-analysis/case-control study引用本文复制引用
张蕾,赵丹丹,李家平,朱园园,沈乾坤,何涛..P53蛋白在葡萄胎中表达的Meta分析[J].临床与病理杂志,2018,38(1):147-155,9.
