临床与病理杂志2018，Vol.38Issue(2)：227-231,5.DOI:10.3978/j.issn.2095-6959.2018.02.001
多肽pATMtide在先天性心脏病中的作用
Effect of pATMtide on congenital heart disease
摘要
Abstract
Objective: To investigate the function of pATMtide in the heart development of zebra fish and differentiation of P19 cells. Methods: An obvious up-regulated polypeptide pATMtide was found from our previous study. In vitro experiment, the effect of pATMtide on P19 cells differentiation were detected; and in vivo experiment, after microinjecting the zygotes zebra fish with pATMtide, the cardiac development of zebra fish was observed. Results: The differentiation and related cardiac biomarkers of P19 cells are reduced as well as the heart development of zebrafish after adding pATMtide. Conclusion: The differentiation and development are influenced after adding pATMtide. It indicates that pATMtide may play an important role in congenital heart disease.关键词
多肽/先天性心脏病/P19细胞/斑马鱼/显微注射Key words
peptides/congenital heart disease/P19 cells/zebra fish/microinjection引用本文复制引用
冯梦文,尹安雯,程子杰,徐佳,章浩,张奇军,李华,钱玲梅..多肽pATMtide在先天性心脏病中的作用[J].临床与病理杂志,2018,38(2):227-231,5.基金项目
国家自然科学基金(81370278,81570209).This work was supported by the National Natural Science Foundation of China (81370278, 81570209). （81370278,81570209）
