临床与病理杂志2018，Vol.38Issue(2)：267-275,9.DOI:10.3978/j.issn.2095-6959.2018.02.007
TRIM24在乳腺癌组织中的表达与患者淋巴节转移的相关性
Correlation of TRIM24 expression with lymph node metastasis in breast carcinoma
摘要
Abstract
Objective: To analyze the expression level of TRIM24 in breast cancer. Methods: By using oncomine online database, expression of TRIM24 gene in breast cancer tissues was analyzed by cluster analysis. In 108 cases of patients from Department of General Surgery, Huashan Hospital Affiliated to Fudan University, the expression and distribution of TRIM24 protein was detected by immunohistochemistry and immunofluorescence. The expression of TRIM24 protein was also detected by Western blot. The correlation between positive expression of TRIM24 and lymph node metastasis in patients was analyzed. Results: The online database including Cancer Genome Atlas (TCGA) showed high expression of TRIM24 in breast cancer tissues, and the expression of TRIM24 protein in breast cancer tissues was significantly higher than that in paracancerous tissues. TRIM24 protein was expressed both in nucleus and cytoplasm. The positive expression of TRIM24 was positively correlated with lymph node metastasis (P＜0.05). Conclusion: High expression of TRIM24 in breast cancer indicates that it is closely related to lymph node metastasis in breast cancer.关键词
乳腺癌/oncomine数据库/TRIM24/淋巴结转移Key words
breast cancer/oncomine database/TRIM24/lymph node metastasis引用本文复制引用
严泓,周竹超..TRIM24在乳腺癌组织中的表达与患者淋巴节转移的相关性[J].临床与病理杂志,2018,38(2):267-275,9.基金项目
上海市卫生和计划生育委员会科研课题(201440579).This work was supported by the Shanghai Municipal Commission of Health and Family Planning, China (201440579) （201440579）
