摘要
Abstract
Objective: To observe the optimum dose of oxycodone for analgesic effect of patient-controlled intravenous analgesia (PCIA) after uterine arterial embolization. Methods: Eighty patients with ASA physical status I-II, aged 35-57 years, undergoing uterine arterial embolization (UAE), were randomly divided into four groups (n=20). 10 minutes before the end of surgery, oxycodone 0.05 mg/kg (Group O1-O3) or 0.9％ NaCl (Group C) were intravenously injected. And then, each patient was given PCIA, with solution including oxycodone 0.5, 0.75, 1.0 mg/kg plus tropisetron 10 mg plus 0.9％ NaCl (100 mL) in Group O1-O3 and no PCIA in Group C. The postoperative score of visual analogue scale (VAS) was maintained <4 points. When VAS scores >4 points or more, pethidine 50 mg was injected for remedy analgesia. Remedy analgesia and adverse reactions was recorded. Results: Compared with Group C, remedy analgesia was decreased significantly in Group O1-O3 (P＜0.05); compared with Group O1, rescue analgesia was decreased in Group O2 and O3 (P＜0.05); there were no difference in Group O2 and Group O3 for rescue analgesia (P＞0.05). For adverse reactions, there were no significant difference in Group C, Group O1 and O2 (P＞0.05); the incidence of adverse reactions of Group O3 was significantly higher than Group C, Group O1 and Group O2 (P＜0.05). Conclusion: The optimum dose of oxycodone for analgesic effect of patient-controlled intravenous analgesia (PCIA) after uterine arterial embolization was 0.75 mg/kg.关键词
羟考酮/子宫动脉栓塞术/镇痛/适宜剂量Key words
oxycodone/uterine artery embolization/analgesia/optimum dose
