摘要
Abstract
Objective: To investigate the correlation analysis between tumor related indicators of diffuse large B-cell lymphoma (DLBCL) and lactate dehydrogenase (LDH) and prognosis in 18F-FDG PET/CT imaging before treatment. Methods: A total of 78 patients with pathologically confirmed DLBCL were selected and 18F-FDG PET/CT imaging performed before treatment. We analyzed the correlation of tumor related markers [maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), total glycolysis of lesions (TLG)] with the level of LDH and prognosis related factors [Ann Arbor stage, international prognostic index (IPI), number of involved nodular sites] by Spearman correlation analysis. With progression-free survival (PFS) as the positive event, the optimal cut-off values of SUVmax, MTV and TLG were obtained through the receiver operating characteristic (ROC) curve. Three-year PFS rates were statistically analyzed, and Cox proportional hazard model was used to analyze independent factors affecting the PFS rate. Results: There was no correlation between SUVmax and Ann Arbor stage, IPI score and the number of involved nodular sites (P＞0.05). MTV and TLG were positively correlated with the LDH level, Ann Arbor stage and IPI score (all P＜0.05). At the end of follow-up, the median PFS time of 78 patients was 33 months, and the 9-year PFS rate was 46.15％. The cut-off values of SUVmax, MTV and TLG were 20.20, 55.86 cm3 and 816.69 g respectively, with PFS as the positive event. Cox multivariate regression analysis showed that Ann Arbor stage, IPI score, MTV and TLG were independent influencing factors of PFS rate in patients with DLBCL. Conclusion: MTV and TLG in 18F-FDG PET/CT imaging before treatment are positively correlated with LDH. Ann Arbor stage and IPI score which are independent factors influencing the PFS of patients with DLBC, while SUVmax is of little significance for predicting the prognosis.关键词
弥漫大B细胞淋巴瘤/18F-FDG PET/CT/乳酸脱氢酶/预后Key words
diffuse large B cell lymphoma/18F-FDG PET/CT/lactate dehydrogenase/prognosis
