广西科学2018，Vol.25Issue(3)：253-257,5.DOI:10.13656/j.cnki.gxkx.20180529.001
酶催化功能混杂性研究进展
A Brief Overview of Catalytic Promiscuity of Enzymes
摘要
Abstract
Enzymes,which catalyze chemical reactions in vivo,are considered as the driving forces for the formation of life metabolism.Compared with the traditional view that enzymes have specific catalytic functions,bioinformatics and experimental analysis in recent years have confirmed that enzymes having a variety of hybrid catalytic functions are universal phenomena.Over the past several billion years,ancient enzymes have evolved to adapt to changing environ-ments,forming a modern and diverse family of enzyme proteins.Catalytic functional promiscui-ty based on unique substrate binding patterns and dynamic protein structure is believed to be the basis for the adaptive evolution of enzyme proteins.The enzymatic miscibility of the enzyme is expected to be exploited in the fields of drug enzymatic synthesis and environmental remedia-tion fields.In this paper,we summarized the related research progresses on the universality,molecular mechanism,and evolvability of enzyme-catalyzed functional promiscuity.关键词
酶/混杂性/分子进化/环境适应/蛋白动态性Key words
enzyme/promiscuity/molecular evolution/environmental adaptation/protein dy-namics分类
生物科学引用本文复制引用
杨键,龙丽娟..酶催化功能混杂性研究进展[J].广西科学,2018,25(3):253-257,5.基金项目
中科院战略性先导科技专项(XDA10030404,XDA13020301),国家自然科学基金青年基金项目(41406193)和广东海洋经济创新发展区域示范项目(GD2012-D01-002)资助. （XDA10030404,XDA13020301）
