广西科学2018，Vol.25Issue(3)：258-261,4.DOI:10.13656/j.cnki.gxkx.20180522.002
细胞色素P450酶生物转化及新催化反应的最新进展
The Latest Advance of Biotransformation and New Cata-lytic Reaction of Cytochrome P450 Enzymes
摘要
Abstract
Cytochrome P450 enzymes(P450s or CYPs)are a widespread large super family of mono-oxygenase that catalyzes the different substrates via heme in life beings.On the one hand,P450s involves in the key step of high-active natural product biosynthetic pathway,its biotransformation studies will help to increase the yield and activity of active molecules.On the other hand,its catalysis involves in metal elements and cofactors,new breakthroughs have been made in the protein modification and new catalytic reaction of P450s.In this article the latest advances in these two aspects of cytochrome P450 enzymes have been summarized and dis-cussed.关键词
酶工程/细胞色素P450酶/生物转化/新催化反应Key words
enzyme engineering/cytochrome P450 enzymes/biotransformation/new catalytic reaction分类
医药卫生引用本文复制引用
潘丽霞,朱婧,王青艳,杨登峰..细胞色素P450酶生物转化及新催化反应的最新进展[J].广西科学,2018,25(3):258-261,4.基金项目
国家自然科学基金项目(31660251)和广西自然科学基金项目(2017GXNSFAA198010)资助. （31660251）
