广西科学2018，Vol.25Issue(3)：262-267,278,7.DOI:10.13656/j.cnki.gxkx.20180612.001
类泛素化修饰Neddylation在心脏生物学中的作用
The Role of Ubiquitin-like Modification of Neddylation in Cardiac Biology
摘要
Abstract
Neural precursor cell-expressed developmentally downregulated 8(NEDD8)is a mem-ber of ubiquitin-like protein family and its structure is similar to that of ubiquitin.Neddylation is a post-translational protein modification that conjugates an ubiquitin-like protein NEDD8 to target proteins,which is mediated by a cascade of three NEDD8 specific enzymes,an E1 activa-ting enzyme,an E2 conjugating enzyme and one of the several E3 ligases.Neddylation abnor-malities have been confirmed to be closely related to various diseases such as cancer,neurode-generative diseases and congenital heart diseases.In recent years,the role of neddylation and deneddylation in the cardiovascular system has attracted much attention.This article will mainly describe the biological processes of neddylation and its role in cardiac biology.关键词
NEDD8/neddylation/deneddylation/心脏疾病/翻译后修饰Key words
NEDD8/neddylation/deneddylation/cardiac disease/post-translational modification分类
医药卫生引用本文复制引用
李双月,苏华波..类泛素化修饰Neddylation在心脏生物学中的作用[J].广西科学,2018,25(3):262-267,278,7.基金项目
US National Institutes of Health Grants (R01HL124248,F31HL139079),American Heart Association Grants (17POST33410592,16SDG30940002). （R01HL124248,F31HL139079）
