广西科学2018，Vol.25Issue(3)：268-273,6.DOI:10.13656/j.cnki.gxkx.20180604.002
逆转录转座子LINE-1的活性调控及其在癌症中的作用
The Regulation of Retrotransposon LINE-1 and Its Function in Tumorigenesis
摘要
Abstract
Long Interspersed Nucleotide Element 1(LINE-1)is a jumping gene that accounts for about 17％of the human genome.LINE-1 translocates through the genome in a"copy-paste"way,using RNA as a medium.Generally,transposition activity of LINE-1 in cells is strictly reg-ulated.In tumor cells,LINE-1 is abnormally activated,affecting the stability of the genome in a Retrotransposon-dependent or non-dependent manner.The former can change the expression of target genes,cause chromatin rearrangement,or assist other transposons(e.g.SINEs,etc.)in transposition.The latter involves in a variety of activities through epigenetic modalities in can-cerous cells,such as the generation of endogenous regulator RNAs,LINE-1 chimeric transcrip-tion,or the supply of new shear sites or variable promoters to change the expression of adjacent genes.This article mainly introduces the composition of LINE-1 and its regulation of transposition activity,and discusses the function of LINE-1 transposition in tumors,in order to provide some references for the in-depth study of LINE-1,the mechanism of tumor formation and therapeutic exploration.关键词
逆转座子/LINE-1/癌症Key words
retrotransposon/LINE-1/tumorigen-esis分类
生物科学引用本文复制引用
朱绮霞,李一向,成春燕,胡文进,周礼芹..逆转录转座子LINE-1的活性调控及其在癌症中的作用[J].广西科学,2018,25(3):268-273,6.基金项目
国家自然科学基金项目(31660018)资助. （31660018）
