广西医学2018，Vol.40Issue(11)：1157-1160,1171,5.DOI:10.11675/j.issn.0253-4304.2018.11.01
烧伤湿润暴露疗法及湿润烧伤膏治疗糖尿病足的效果及对创面组织血管内皮生长因子和表皮细胞生长因子水平的影响
Efficacy of moist exposed burn therapy/moist exposed burn ointment for diabetic foot and its effect on vascular endothelial growth factor and epidermal growth factor of ulcer wounds
摘要
Abstract
Objective To observe the efficacy of moist exposed burn therapy/moist exposed burn ointment(MEBT/MEBO) for diabetic foot and its effect on vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) of ulcer wounds. Methods Fifty-eight patients with diabetic foot ulcer were randomly divided into study group and control group,with 29 cases in each group. The study group was treated with MEBT/MEBO,while the control group was treated with recombinant bovine basic fibroblast growth factor. The clinical efficacy and symptom score for local wounds after treatment,as well as the wound areas and the levels of VEGF and EGF of ulcer wounds before treatment and after 14 and 28 days of treatment,were compared between the two groups. Results After 28 days of treatment,the area of ulcer was smaller,the depth of ulcer was less,and the scores of local symptoms and signs were lower in the study group compared to those in the control group(all P＜0. 05);the clinical efficacy in the study group was superior to that in the control group(P＜0. 05). On the 14th and 28th day after treatment,the levels of VEGF and EGF in the study group were higher than those in the control group(all P＜0. 05). Conclusion MEBT/MEBO can promote wound healing in the treatment of diabetic foot ulcer which might be associated with upregulating the levels of growth factors of ulcer wounds.关键词
糖尿病足/皮肤再生医疗技术/烧伤湿润暴露疗法/湿润烧伤膏/血管内皮生长因子/表皮细胞生长因子Key words
Diabetic foot ulcer/Skin regeneration technology/Moist exposed burn therapy/Moist exposed burn ointment/Vascular endothelial growth factor/Epidermal growth factor分类
医药卫生引用本文复制引用
刘明,唐乾利,李杰辉,黄仲海,张春霞,狄钾骐,黄许森,刘雪琴..烧伤湿润暴露疗法及湿润烧伤膏治疗糖尿病足的效果及对创面组织血管内皮生长因子和表皮细胞生长因子水平的影响[J].广西医学,2018,40(11):1157-1160,1171,5.基金项目
国家自然科学基金( 81660793 ) （ 81660793 ）
广西科技计划项目(桂科 AB17292046 ) （桂科 AB17292046 ）
广西中医药民族医药科研课题(GZZC15005) （GZZC15005）
