广西医学2018，Vol.40Issue(11)：1174-1177,4.DOI:10.11675/j.issn.0253-4304.2018.11.06
体外受精-胚胎移植促排卵早期添加重组人黄体生成素在低黄体生成素患者中的应用效果
Effect of early recombinant human luteinizing hormone supplementation during ovulation induction applied to in vitro fertilization-embryo transfer on patients with low luteinizing hormone
摘要
Abstract
Objective To explore the effect of early recombinant human luteinizing hormone(r-hLH) supplementation during the ovulation induction applied to in vitro fertilization and embryo transfer ( IVF-ET) on the patients with low luteinizing hormon ( LH). Methods A total of 306 patients with low LH undergoing IVF-ET,who were treated with a long ovulation induction protocol in luteal phase, were divided into group A(85 cases),group B(166 cases) and group C(55 cases). Group A and group B received r-hLH supplementation on the 1st and 5th day respectively after gonadotropin(Gn) protocol launching,while group C was given Gn alone without r-hLH. The amount of and duration of Gn used,serum estradiol(E2) and LH levels on the day of human chorionic gonadotropin(hCG) injection,endometrial thickness, number of retrieved oocytes,number of embryo transfer,normal fertilization rate,high-quality embryo rate,implantation rate and clinical pregnancy rate were compared among the three groups. Results The amounts of Gn of group A,group B and group C increased in turn(all P＜0. 05),and the duration of Gn used in group C was longer than that in group A or B(all P＜0. 05);there were no statistically significant differences among the three groups in the E2or LH level,endometrial thickness,number of retrieved oocytes,or mean number of embryo transfer(all P＞0. 05);the normal fertilization rates and high-quality embryo rates of group A,group B and group C decreased in turn(all P＜0. 05),and the implantation rate and clinical pregnancy rate in group C were lower than those in group A or B(all P ＜0. 05). Conclusion r-hLH supplementation during the ovulation induction, especially used in early stage, might contribute to improving the pregnancy outcome of patients with oversuppressed LH after IVF-ET with a long proposal of pituitary down-regulation.关键词
体外受精-胚胎移植/低黄体生成素水平/重组人黄体生成素/促排卵Key words
In vitro fertilization and embryo transfer/Low luteinizing hormone level/Recombinant human luteinizing hormone/ Ovulation induction分类
医药卫生引用本文复制引用
谭秀群,李汝斐,农柳莹,丘映..体外受精-胚胎移植促排卵早期添加重组人黄体生成素在低黄体生成素患者中的应用效果[J].广西医学,2018,40(11):1174-1177,4.基金项目
广西南宁市科学研究与技术开发计划(20123139) （20123139）
