广西医学2018，Vol.40Issue(11)：1189-1191,3.DOI:10.11675/j.issn.0253-4304.2018.11.10
妊娠期糖尿病患者产后血清视黄醇结合蛋白4、转化生长因子β1水平及临床意义
Puerperal levels and clinical significance of serum retinol binding protein 4 and transforming growth factor beta 1 in patients with gestational diabetes mellitus
黄晓燕 1韦柳情1
作者信息
- 1. 广西河池市人民医院妇产科,河池市 547400,
- 折叠
摘要
Abstract
Objective To explore the puerperal levels and clinical significance of serum retinol binding protein 4( RBP4) and transforming growth factor beta 1(TGF-β1) in the patients with gestational diabetes mellitus(GDM). Methods Sixty-one patients with GDM(observation group) and 50 normal pregnant women(control group) were enrolled. Serum levels of RBP4 and TGF-β1at 2 and 4 months after delivery as well as the FBG and fasting insulin(FINS) levels were detected in both groups. Homeostasis Model Assessment of Insulin Resistance(HOMA-IR) index was counted. Results Compared to the control group,the observation group obtained higher levels of serum RBP4 and TGF-β1at 2 and 4 months after delivery as well as higher FBG and HOMA-IR(P＜0. 05). There was no significant difference in the FINS level between the two groups(P＞0. 05). In the patients with GDM,the puerperal levels of serum RBP4 and TGF-β1positively correlated with FBG and HOMA-IR,and serum RBP4 level positively correlated with serum TGF-β1level(P＜0. 05). Conclusion Serum levels of RBP4 and TGF-β1increase significantly in the patients with GDM after delivery,and can be the effective indices for monitoring the puerperal glycometabolism abnormality in patients with GDM.关键词
妊娠期糖尿病/产后/视黄醇结合蛋白4/转化生长因子β1Key words
Gestational diabetes mellitus/Postpartum/Retinol binding protein 4/Transforming growth factor beta 1分类
医药卫生引用本文复制引用
黄晓燕,韦柳情..妊娠期糖尿病患者产后血清视黄醇结合蛋白4、转化生长因子β1水平及临床意义[J].广西医学,2018,40(11):1189-1191,3.
