摘要
Abstract
Objective :To study the correlation of serum complements C3 and C4 as well as immunoglobulins IgM ,IgA and IgG contents with inflammatory stress response in children with mycoplasma pneumoniae pneumonia .Methods :The chil-dren who were diagnosed with mycoplasma pneumoniae pneumonia in Xiangyang No .1 Peopleˊs Hospital ,Hubei University of Medicine between February 2015 and January 2018 were selected as the MPP group ,and healthy children who received physical examination during the same period were selected as the control group .The contents of complements ,immunoglobulins and in-flammatory stress mediators in serum as well as the expression of inflammatory stress molecules in peripheral blood were measured .Results :Serum C3 ,C4 ,IgM ,sICAM-1 ,CD40L ,HMGB1 ,Cor and MDA levels as well as peripheral blood TLR2 , TLR4 ,CD11b ,CD18 ,MPO and NOX2 expression intensity of MPP group were significantly higher than those of control group ,IgA level was significantly lower than that of control group ,and IgG level was not different from that of control group ;serum C3 ,C4 and IgM levels of MPP group were positively correlated with serum sICAM-1 ,CD40L ,HMGB1 ,Cor and MDA levels as well as peripheral blood TLR2 ,TLR4 ,CD11b ,CD18 ,MPO and NOX2 expression intensity ,and serum IgA level was negatively correlated with serum sICAM-1 ,CD40L ,HMGB1 ,Cor and MDA levels as well as peripheral blood TLR2 , TLR4 ,CD11b ,CD18 ,MPO and NOX2 expression intensity .Conclusion :The changes of serum complements and immuno-globulins in children with mycoplasma pneumoniae pneumonia are related to the excessive activation of inflammatory stress re-sponse in the course of disease .关键词
支原体肺炎/补体/免疫球蛋白/炎症反应/应激反应Key words
Mycoplasma pneumoniae pneumonia/Complement/Immunoglobulin/Inflammatory response/Stress re-sponse分类
医药卫生
