摘要
Abstract
Objective :To explore the influence on liver function of hepatic artery interventional chemoembolization com-bined reduced glutathione therapy for elderly patients with advanced liver cancer .Methods :A total of 120 cases of elderly pa-tients with advanced liver cancer from digestive surgery in-patient department of our hospital during the period of January 2014 and January 2016 were selected as the research object ;the patients were divided into two groups by using the random number table method ,with 60 cases in each group .The control group were given conventional drugs chemotherapy ,while the study group were given hepatic artery interventional chemoembolization combined reduced glutathione therapy .Serum liver function indexes of Direct Bilirubin (DBil) ,Total Bilirubin (TBil) ,Aspartate Transaminase (AST ) and Alanineamino Transferase (ALT ) were detected by using automatic biochemical analyzer .Results :The clinical remission rate of study group was signifi-cantly higher than the control group ;the recurrence rate was obviously lower than the control group ,compared between the two groups with statistically significant differences (P＜0 .05).The average survival time of study group (29 .36 ± 6 .25) months was significantly longer than the control group (18 .02 ± 4 .16) months (P＜0 .05).Before the treatment ,serum DBil ,TBil , AST and ALT levels compared between the two groups with no statistically significant differences (P＞0 .05) ;after the treat-ment ,the indexes of study group was significantly lower than the control group (P＜0 .05).The indexes levels compared be-tween pre-therapy and post-therapy in study group with no statistically significant differences (P＞0 .05) ,while the indexes lev-els of post-therapy in the control group were significantly higher than those pre-therapy (P＜0 .05).Before the treatment ,the life quality score compared between the two groups with no statistically significant differences (P＞0 .05) ;after treatment ,the score of all patients were significantly higher than those pre-therapy (P＜0 .05) ,which the score of study group was signifi-cantly higher than the control group (P＜0 .05).The incidence rate of drug adverse reactions compared between the two groups with no statistically significant differences (P＞0 .05).Conclusion :The clinical efficacy of hepatic artery interventional chemo-embolization combined reduced glutathione therapy for elderly patients with advanced liver cancer is satisfying ,and helps to significantly improve liver function ,improve life quality ;it is worthy of popularization and application in the clinical practice .关键词
肝动脉介入化疗栓塞术/还原型谷胱甘肽/老年/晚期肝癌/肝功能Key words
Hepatic/artery/interventional/chemoembolization/,Reduced/glutathione/,Elderly/,Advanced/liver/cancer/,/Liver/function分类
医药卫生
