海南医学院学报2018，Vol.24Issue(11)：1109-1112,4.DOI:10.13210/j.cnki.jhmu.20180425.003
血清STMN1、Cath-D含量与宫颈癌病灶浸润性生长的相关性
The correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer
摘要
Abstract
Objective :To study the correlation of serum stathmin 1 (STMN1) and cathepsin D (Cath-D) levels with the invasive growth of cervical cancer .Methods :The patients with cervical cancer and those with uterine fibroids who underwent surgical resection in the Second Peopleˊs Hospital of Yichang between January 2013 and November 2017 were selected and en-rolled in the malignant group and the benign group of the study respectively ;the serum was collected before operation to detect the contents of STMN1 and Cath-D ;the cervical cancer lesion tissues were collected from the malignant group and the normal cervical tissues were collected from the benign group to measure the expression of STMN 1 ,Cath-D ,invasion genes and inva-sion signal molecules .Results :STMN1 and Cath-D contents in serum as well as STMN1 and Cath-D mRNA expression in le-sion tissue of malignant group were significantly higher than those of benign group ,and serum STMN1 and Cath-D contents of malignant group were positively correlated with STMN1 and Cath-D mRNA expression in lesion tissue ;RACK1 ,Twist , MMP9 ,mTOR ,S6K1 ,Wnt and β-catenin mRNA expression in lesion tissue of malignant group were significantly higher than those of benign group whereas E-cadherin ,GRIM19 and GSK-3β mRNA expression were significantly lower than those of be-nign group ,and serum STMN1 and Cath-D contents of malignant group were positively correlated with RACK1 ,Twist , MMP9 ,mTOR ,S6K1 ,Wnt and β-catenin mRNA expression in lesion tissue ,and negatively correlated with E-cadherin , GRIM19 and GSK-3β mRNA expression .Conclusion :The abnormally elevated STMN1 and Cath-D in serum of patients with cervical cancer can evaluate the invasive growth of the lesion .关键词
宫颈癌/微管解聚蛋白1/组织蛋白酶D/侵袭/信号通路Key words
cervical cancer/stathmin 1/cathepsin D/invasion/signaling pathway分类
医药卫生引用本文复制引用
赵春莲,李晓兰,陈小霞,谢玲玲,王熙,田洁,周栩茹..血清STMN1、Cath-D含量与宫颈癌病灶浸润性生长的相关性[J].海南医学院学报,2018,24(11):1109-1112,4.基金项目
It is supported by Scientific Research Project of Hubei Provincial Science and Technology Department (2015CFB574). 湖北省科技厅科研项目(2015CFB574) （2015CFB574）
