海南医学院学报2018，Vol.24Issue(11)：1131-1134,4.DOI:10.13210/j.cnki.jhmu.20180416.003
右佐匹克隆与艾司唑仑对脑卒中后失眠患者神经递质、神经细胞因子及应激状态的影响
Effects of dexzopiclone and estazolam on neurotransmitters, nerve cytokines and stress states in patients with insomnia after stroke
摘要
Abstract
Objective :To study the effects of dexzopiclone and estazolam on neurotransmitters ,nerve cytokines and stress states in patients with insomnia after stroke .Methods :The patients with insomnia after stroke who were treated in Linyi Rongjun Hospital between March 2015 and October 2017 were chosen and randomly divided into dexzopiclone group and es-tazolam group .The levels of neurotransmitters ,nerve cytokines and stress indexes in serum were measured before treatment as well as 14 days and 28 days after treatment .Results :Compared with those before treatment ,serum Glu ,γ-GABA ,5-HT ,5-HIAA ,BDNF and NGF levels of both groups significantly increased whereas NE ,TNF-α ,IL-6 ,ATCH ,Cor ,CRP ,SOD and GSH levels significantly decreased after treatment ,and serum Glu ,γ-GABA ,5-HT ,5-HIAA ,BDNF and NGF levels of dexzopiclone group after treatment were higher than those of estazolam group whereas NE ,TNF-α ,IL-6 ,ATCH ,Cor ,CRP , SOD and GSH levels were lower than those of estazolam group .Conclusion :Dexzopiclone is more effective than estazolam to regulate the secretion of neurotransmitters and nerve cytokines and reduce the stress state in patients with insomnia after stroke.关键词
右佐匹克隆/艾司唑仑/脑卒中后失眠/神经递质/神经细胞因子Key words
dexzopiclone/estazolam/insomnia after stroke/neurotransmitter/nerve cytokine分类
医药卫生引用本文复制引用
李秀泉..右佐匹克隆与艾司唑仑对脑卒中后失眠患者神经递质、神经细胞因子及应激状态的影响[J].海南医学院学报,2018,24(11):1131-1134,4.基金项目
It is supported by Shandong Provincial Plan Project for Medical Health Scientific Technology Development (2016WSA13084). 山东省医药卫生科技发展计划项目(2016WSA13084) （2016WSA13084）
