海南医学院学报2018，Vol.24Issue(12)：1151-1154,4.DOI:10.13210/j.cnki.jhmu.20180424.002
三联活菌胶囊联合抗生素治疗对自发性细菌性腹膜炎患者炎性因子、肠粘膜屏障功能的影响
Effect of Triple Viable Capsule combined with antibiotic therapy on the inflammatory factors and intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis
摘要
Abstract
Objective :To study the effect of Triple Viable Capsule combined with antibiotic therapy on the inflammato-ry factors and intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis.Methods :Patients with cir-rhosis combined with spontaneous bacterial peritonitis who were treated in Traditional Chinese Medicine Hospital of Shehong County between March 2015 and October 2017 were selected and randomly divided into the observation group who accepted Triple Viable Capsule combined with antibiotic therapy and the control group who accepted conventional symptomatic treat-ment.The levels of inflammatory factors and intestinal mucosal barrier markers in serum as well as the number of intestinal flora in feces were detected before treatment and 2 weeks after treatment.Results :Compared with those of same group before treatment ,PCT ,CRP ,sTREM-1 ,MCP-1 ,TNF-α ,IFN-γ ,DAO ,D-lactic acid ,LPS ,Occludin and ZO-1 levels in serum as well as the number of enterobacter and enterococcus in feces of both groups of patients were lower whereas the number of bifidobacterium ,lactobacillus and clostridium leptum were higher after treatment ,and PCT ,CRP ,sTREM-1 ,MCP-1 ,TNF-α ,IFN-γ ,DAO ,D-lactic acid ,LPS ,Occludin and ZO-1 levels in serum as well as the number of enterobacter and enterococ-cus in feces of observation group after treatment were lower than those of control group whereas the number of bifidobacteri-um ,lactobacillus and clostridium leptum were higher than those of control group.Conclusion :Triple Viable Capsule combined with antibiotic therapy can inhibit the secretion of inflammatory cytokines and improve the intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis.关键词
自发性细菌性腹膜炎/三联活菌胶囊/炎性因子/肠黏膜屏障/肠道菌群Key words
spontaneous bacterial peritonitis/Triple Viable Capsule/inflammatory factor/intestinal mucosal barrier/intestinal flora分类
医药卫生引用本文复制引用
郑宏斌..三联活菌胶囊联合抗生素治疗对自发性细菌性腹膜炎患者炎性因子、肠粘膜屏障功能的影响[J].海南医学院学报,2018,24(12):1151-1154,4.基金项目
This study was supported by Scientific Research Project of Sichuan Provincial Department of Health (grant No .120326) （grant No .120326）
四川省卫生厅科研课题(120326) （120326）
