海南医学院学报2018，Vol.24Issue(12)：1159-1162,4.DOI:10.13210/j.cnki.jhmu.20180503.004
氟比洛芬酯用于膝关节置换术后镇痛对血清和关节液中细胞因子含量、HPA轴活性的影响
Effect of flurbiprofen axetil analgesia after knee replacement on the cytokine contents in ser-um and joint fluid as well as HPA axis activity
摘要
Abstract
Objective :To investigate the effect of flurbiprofen axetil analgesia after knee replacement on the cytokine contents in serum and joint fluid as well as HPA axis activity.Methods :Patients who underwent knee replacement in People's Hospital of Dongxihu District of Wuhan City between April 2015 and January 2018 were selected as the research subjects and randomly divided into the experimental group who accepted flurbiprofen axetil combined with patient-controlled intravenous an-algesia and the control group who accepted patient-controlled intravenous analgesia alone.The contents of cytokines and HPA axis-related hormones in serum were measured before surgery as well as 1 day and 3 days after surgery ;the contents of cyto-kines in joint fluid were measured 1 day and 3 days after surgery.Results :Compared with those of same group before surgery , NGF ,NPY ,TNF-α ,IL-2 ,IL-4 ,IL-10 ,ACTH ,COR ,INS ,GH and PRL levels of both groups were increasing 1 day and 3 days after surgery ,and NGF ,NPY ,TNF-α ,IL-2 ,IL-4 ,IL-10 ,ACTH ,COR ,INS ,GH and PRL levels in serum as well as PGE2 ,OPN ,TGF-β1 ,FGF21 ,CXCL12 and YKL-40 in joint fluid of experimental group 1 day and 3 days after surgery were lower than those of control group (P＜0.05).Conclusion :Flurbiprofen axetil analgesia after knee replacement can reduce the release of cytokines in serum and joint fluid ,and inhibit the activity of HPA axis ,and its analgesic effect is exact.关键词
膝关节置换术/氟比洛芬酯/细胞因子/HPA轴Key words
Knee replacement/Flurbiprofen axetil/Cytokine/HPA axis分类
医药卫生引用本文复制引用
林浩,柳春霞..氟比洛芬酯用于膝关节置换术后镇痛对血清和关节液中细胞因子含量、HPA轴活性的影响[J].海南医学院学报,2018,24(12):1159-1162,4.基金项目
This study was supported by Wuhan Municipal Science and Technology General Project (Grant No .CT152724) （Grant No .CT152724）
武汉市科技一般项目(CT152724) （CT152724）
