海南医学院学报2018，Vol.24Issue(12)：1179-1182,4.DOI:10.13210/j.cnki.jhmu.20180428.002
小剂量糖皮质激素+阿奇霉素治疗小儿大叶性肺炎的疗效分析
Curative effect of small-dose glucocorticoids + azithromycin treatment on lobar pneumonia
摘要
Abstract
Objective :To study the effect of small-dose glucocorticoids + azithromycin therapy on inflammatory re-sponse and stress response in children with lobar pneumonia.Methods :Children with mycoplasma pneumoniae lobar pneumonia who were treated in the First People's Hospital of Ziyang between January 2015 and January 2018 were chosen as the research subjects and randomly divided into two groups :GCs group were treated with low-dose glucocorticoids + azithromycin ,and control group were treated with azithromycin.The inflammatory response indicators and stress response indicators in serum and peripheral blood were measured before treatment as well as 3d and 5d after treatment.Results :Compared with those of same group before treatment ,peripheral blood TLR4 ,NF-κB ,NOX2 ,p38MAPK ,iNOS ,GRP78 ,PERK ,ATF4 ,CHOP and Caspase-12 expression intensity as well as serum TNF-α ,HMGB-1 ,ICAM-1 ,NO ,MDA and 8-OhdG levels of both groups significantly decreased after treatment (P＜0.05) ,and peripheral blood TLR4 ,NF-κB ,NOX2 ,p38MAPK ,iNOS ,GRP78 , PERK ,ATF4 ,CHOP and Caspase-12 expression intensity as well as serum TNF-α ,HMGB-1 ,ICAM-1 ,NO ,MDA and 8-OhdG levels of GCs group after treatment were significantly lower than those of control group (P＜0.05).Conclusion :Small- dose glucocorticoid + azithromycin therapy is more effective than azithromycin therapy to suppress the inflammatory and stress response in children with lobar pneumonia.关键词
大叶性肺炎/糖皮质激素/阿奇霉素/炎症反应/应激反应Key words
Lobar Pneumonia/Glucocorticoids/Azithromycin/Inflammatory response/Stress response分类
医药卫生引用本文复制引用
张利..小剂量糖皮质激素+阿奇霉素治疗小儿大叶性肺炎的疗效分析[J].海南医学院学报,2018,24(12):1179-1182,4.基金项目
This study was supported by the Special Fund for Women and Children of Sichuan Provincial Science and Technology Department (Grant No .Ck13 f113) （Grant No .Ck13 f113）
四川科技厅妇儿专项基金(Ck13f113) （Ck13f113）
