海南医学院学报2018，Vol.24Issue(12)：1191-1195,5.DOI:10.13210/j.cnki.jhmu.20180503.003
垂体瘤病灶内LRlG1、Gadd45g表达量与肿瘤细胞自噬、凋亡、侵袭的相关性研究
The correlation of LRlG1 and Gadd45g expression in pituitary tumor with the autophagy ,ap-optosis and invasion of tumor cells
摘要
Abstract
Objective :To study the correlation of LRIG1 and Gadd45g expression in pituitary tumor with the autophagy , apoptosis and invasion of tumor cells.Methods :Patients with pituitary tumor who underwent surgical resection in our hospital between June 2014 and December 2017 were selected ,and the invasive pituitary tumor tissues and noninvasive pituitary tumor tissues were collected ;patients who underwent surgery for craniocerebral trauma in our hospital during the same period were selected as the control group ,and normal brain tissues were collected ;the mRNA expression levels of LRIG1 ,Gadd45g as well as autophagy ,apoptosis and invasion genes in tissue samples were measured.Results :LRIG1 ,Gadd45g ,Beclin1 ,LC3-II , Bax ,NKG2D and E-cadherin mRNA expression in invasive pituitary tumor and noninvasive pituitary tumor tissues were signif-icantly (P＜0.05) lower than those in normal brain tissues whereas PTTG1 ,c-Myc ,Gal-3 ,Bcl-2 ,EphA2 ,HSP27 ,MMP14 and VEGF mRNA expression were significantly (P＜0.05) higher than those in normal brain tissues ,and LRIG1 ,Gadd45g , Beclin1 ,LC3-II ,Bax ,NKG2D and E-cadherin mRNA expression in invasive pituitary tumor tissues were significantly (P＜0. 05) lower than those in noninvasive pituitary tumor tissues whereas PTTG1 ,c-Myc ,Gal-3 ,Bcl-2 ,EphA2 ,HSP27 ,MMP14 and VEGF mRNA expression were significantly (P＜0.05) higher than those in noninvasive pituitary tumor tissues ;LRIG1 and Gadd45g mRNA expression were positively correlated with Beclin1 ,LC3-II ,Bax ,NKG2D and E-cadherin mRNA expres-sion ,and negatively correlated with PTTG1 ,c-Myc ,Gal-3 ,Bcl-2 ,EphA2 ,HSP27 ,MMP14 and VEGF mRNA expression. Conclusion :The low expression of LRIG1 and Gadd45g in pituitary tumor can inhibit the autophagy and apoptosis of tumor cells and promote the invasion of tumor cells.关键词
垂体瘤/富含亮氨酸重复序列免疫球蛋白样蛋白1/生长阻滞及DNA损伤诱导基因45g/自噬/凋亡/侵袭Key words
Pituitary tumor/Leucine-rich repeats and immunoglobulin-like domains 1/Growth arrest and DNA dam-age 45g/Autophagy/Apoptosis/Invasion分类
医药卫生引用本文复制引用
秦君翔,喻军华..垂体瘤病灶内LRlG1、Gadd45g表达量与肿瘤细胞自噬、凋亡、侵袭的相关性研究[J].海南医学院学报,2018,24(12):1191-1195,5.基金项目
This study was supported by Natural Science Fund of Hubei Province [Grant No .(2012)30] （2012）
湖北省自然科学基金项目 [(2012)30号] （2012）
