解放军医药杂志2018，Vol.30Issue(6)：1-4,4.DOI:10.3969/j.issn.2095-140X.2018.06.001
不同剂型和负荷剂量西罗莫司的毒性作用分析
Toxic Effects of Different Dosage Forms and Loading Doses of Sirolimus
摘要
Abstract
Objective To analyze effects of different dosage forms and loading doses of Sirolimus on survival ef-ficiency and toxicity of rats. Methods A total of 60 male SD rats were randomly divided into group A1 (general gavage by tablet, 1 mg/kg, 1 time/d, n=10), group A2 (slow-release gavage by tablets, 1 mg/kg, 1 time/d, n=10), group A3 (slow-release gavage by tablets, 0. 5 mg/kg, 1 time/d, n=10), group B1 (general gavage by oral solution, 1 mg/kg, 1 time/d, n=10), group B2 (slow-release gavage by oral solution, 1 mg/kg,1 time/d, n=10) and B3 group (slow-release gavage by oral solution, 0. 5 mg/kg, 1 time/d, n=10). The experiment was lasted for 30 d. Survival effi-ciency and toxic effects including diet condition, body weight, organ lesions, mortality rate and survival time were ob-served in 6 groups. Results At the 30thday, the differences in body weight among group A1, A2 and A3 were statisti-cally significant (P<0. 01), and the differences in body weight among group B1, B2 and B3 were also statistically sig-nificant (P<0. 01). Mortality rate in group A1 was significantly higher than that in group A2 (P=0. 025), and mortali-ty rate in group A2 was significantly higher than that in group A3 ( P=0. 019). Mortality rate in group B1 was signifi-cantly higher than that in group B2 (P=0. 025), but there was no significant difference in mortality rate between group B2 and B3 (P=0. 06). Low load groups had good survival efficiency and significantly longer survival time, and the differences among groups were statistically significant (P<0. 01). Compared with those in high load groups, numbers of lesions in liver, lung and stomach viscera in low load groups were decreased, and lesion degrees were mild. Conclusion Low dosage slow-release intervention (0. 5 mg/kg) of Sirolimus may significantly reduce mortality rate and prolong sur-vival time with less toxic and side-effect and good survival efficiency.关键词
西罗莫司/剂型/药物毒性/大鼠,Sprague-DawleyKey words
Sirolimus/Dosage forms/Drug toxicity/Rats, Sprague-Dawley分类
医药卫生引用本文复制引用
孔祥瑞,李静,周林,肖漓,石炳毅..不同剂型和负荷剂量西罗莫司的毒性作用分析[J].解放军医药杂志,2018,30(6):1-4,4.基金项目
解放军309医院院内课题(2016MS-003) （2016MS-003）
