解放军医药杂志2018，Vol.30Issue(6)：18-21,4.DOI:10.3969/j.issn.2095-140X.2018.06.005
循环肿瘤细胞检测对结直肠癌患者根治术后异时性肝转移的预测价值分析
Value of Circulating Tumor Cell Detection in Prediction of Metachronous Liver Metastasis after Radical Resec-tion for Colorectal Cancer
摘要
Abstract
Objective To investigate value of circulating tumor cells (CTC) detection in prediction of metachro-nous liver metastasis after radical resection for colorectal cancer. Methods Clinical data of 80 patients with colorectal cancer admitted during January 2013 and January 2016 was retrospectively analyzed, and sex, age, pathological features of tumor, CTC expression and incidence rate of metachronous liver metastasis were recorded, and then differences of the above indexes were compared among patients with different CTC expressions. Relationship between CTC expression with clinico-pathological features in colorectal cancer patients was analyzed, and risk factors induced metachronous liver metastasis after radical resection for colorectal cancer were also studied. Results There were significant differences in depth of tumor infil-tration, degree of tumor differentiation, metastasis of lymph nodes, tumor size and incidence rate of metachronous liver me-tastasis between positive and the negative CTC groups (P<0. 05). CTC expression was positively correlated with depth of tumor infiltration, tumor size and metastasis rate of lymph node, and it was negatively correlated with degree of tumor differ-entiation (P<0. 05). Deep tumor infiltration, lymph node metastasis, poorly differentiated tumors, tumor diamenter equal or larger than 5 cm and positive CTC expression were independent risk factors for metachronous liver metastasis after radical resection for colorectal cancer (P<0. 05). Conclusion Positive CTC expression is associated with clinicopathological fea-tures of colorectal cancer patients, and it is an independent risk factor affecting metachronous liver metastasis after radical resection for colorectal cancer, and therefore CTC detection can be used as an effective evaluation method in clinic.关键词
结直肠癌/肿瘤细胞,循环/异时性肝转移/预测Key words
Colorectal neoplasms/Neoplastic cells, circulating/Metachronous liver metastasis/Forecasting分类
医药卫生引用本文复制引用
张振毫..循环肿瘤细胞检测对结直肠癌患者根治术后异时性肝转移的预测价值分析[J].解放军医药杂志,2018,30(6):18-21,4.基金项目
湖北省卫生和计划生育委员会科研基金资助项目(JX1B055) （JX1B055）
