解放军医药杂志2018，Vol.30Issue(6)：42-45,4.DOI:10.3969/j.issn.2095-140X.2018.06.011
急性冠状动脉综合征患者血浆微囊泡浓度及其与冠状动脉粥样硬化斑块稳定性的相关性分析
Correlation between Plasma Microvesicle Concentration with Coronary Atherosclerotic Plaque Stability in Pa-tients with Acute Coronary Syndrome
摘要
Abstract
Objective To investigate correlation between plasma microvesicle concentration with coronary ather-osclerotic plaque stability in patients with acute coronary syndrome (ACS). Methods A total of 108 ACS patients ad-mitted during January 2012 and December 2016 were divided into stable plaque group ( n =24) and unstable plaque group (n=84) according to conditions of coronary atherosclerotic plaques, and other 40 healthy people taking physical examination at the same period were selected as control group. Plasma microvesicle concentration, C-reactive protein (CRP), matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) levels and conditions of coronary atherosclerotic plaque were compared, and correlations between CRP, MMP-1 and plasma microvesicles with coronary atherosclerotic plaques were also analyzed in all groups. Results Value of CRP, MMP-1, TIMP-1 and plasma microvesicle concentration in unstable and stable plaque groups were significantly higher than those in control group, and values of CRP, MMP-1 and plasma microvesicle concentration in unstable plaque group were significantly higher than those in stable plaque group (P<0. 05). In unstable plaque group, ratio of lipid to plaque and area of lipid or non-echo were significantly higher, while values of area stenosis rate and thickness of fibrous cap were significantly lower than those in stable plaque group (P<0. 01). CRP, MMP-1 and plasma microvesicles were positively correlated with ratio of lipid to plaque and area of lipid or non-echo, and they were negatively correlated with area stenosis rate and thickness of fi-brous cap (P<0. 05). Conclusion Plasma microvesicle concentration in ACS patients can be found significantly higher than that in normal population, and it is associated with stability of coronary atherosclerotic plaques.关键词
急性冠状动脉综合征/微囊泡/冠状动脉粥样硬化斑块Key words
Acute coronary syndrome/Microvesicles/Coronary atherosclerotic plaque分类
医药卫生引用本文复制引用
杨玉亚,冯六六,刘天华..急性冠状动脉综合征患者血浆微囊泡浓度及其与冠状动脉粥样硬化斑块稳定性的相关性分析[J].解放军医药杂志,2018,30(6):42-45,4.基金项目
上海市医学重点专科建设计划(ZK2015B23) （ZK2015B23）
